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Department of Medicine

  

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Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.


  • Latest High-Impact Publications
  • Latest Grants, $1 Million and Above
   

IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a
Amatya N, Childs EE, Cruz JA, Aggor FEY, Garg AV, Berman AJ, Gudjonsson JE, Atasoy U, Gaffen SL.
Sci Signal. 2018 Oct 9;11(551). pii: eaat4617. doi: 10.1126/scisignal.aat4617.

 

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H1, Owens GK.
Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5.

 

Use of Palliative Care Earlier in the Disease Course in the Context of the Opioid Epidemic: Educational, Research, and Policy Issues.
Schenker , Merlin JS, Quill TE.
JAMA. 2018 Sep 4;320(9):871-872. doi: 10.1001/jama.2018.9739

 

A Randomized Trial of a Family-Support Intervention in Intensive Care Units
White DB, Angus DC, Shields AM, Buddadhumaruk P, Pidro C, Paner C, Chaitin E, Chang CH, Pike F, Weissfeld L, Kahn JM, Darby JM, Kowinsky A, Martin S, Arnold RM; PARTNER Investigators.
N Engl J Med. 2018 Jun 21;378(25):2365-2375. doi: 10.1056/NEJMoa1802637.

 

Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence.
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE.
JAMA. 2018 May 15;319(19):2021-2031.
PMID: 29800214

 

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J,  Zhang L.
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3930-3935.
PMID: 29581256

 

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML4 Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR ,Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV; National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP).
J Clin Invest. 2018 Mar 1;128(3):997-1009
PMID: 29400693

 

Drug Interactions With Non-Vitamin K Oral Anticoagulants.
Linnebur SA, Hanlon JT.
JAMA. 2018 Feb 27;319(8):828-829.
PMID: 29486025

 

Future of nonnucleoside reverse transcriptase inhibitors. 
Sluis-Cremer N.
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):637-638.
PMID: 29326232

 

Lipid metabolic reprogramming in hepatic ischemia-reperfusion injury.
Monga SP.
Nat Med. 2018 Jan 9;24(1):6-7.
PMID: 29315298

 

 

PI: Richard H. Duerr, MD, Division of Gastroenterology, Hepatology and Nutrition
Agency: NIDDK
Title: NIDDK IBD Genetics Consortium Genetic Research Center
Project timeline: 9/30/2017 to 7/31/2022
Direct Costs: $1,472,617
Indirect Costs: $747,262

 

PI: Eva Szigethy, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition
Agency: PCORI
Title: Specialty Medical Homes to Improve Outcomes for Patients with Inflammatory Bowel Disease and Behavioral Health Conditions
Project timeline: 02/01/2019 – 07/31/2023
Direct Costs: $4,478,571
Indirect Costs: $1,821,429

 

PI: Mark Gladwin, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: BURROUG
Title: A Physician Scientist Incubator
Project timeline: 9/1/2018 – 8/31/2023
Direct Costs: $2,500,000
Indirect Costs: $0
Type of Grant: RES

 

PI: Kong Chen, PhD, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Epigenetic Regulation of Chemokines in Lung Inflammation
Project timeline: 9/1/2018 – 8/31/2022
Direct Costs: $1,021,948
Indirect Costs: $554,569
Type of Grant: R01

 

PI: Flordeliza S. Villanueva, MD, Division of Cardiology
Agency: NIBIB
Title: Biological and Physical Mechanisms of Ultrasound/Microbubble-Mediated Therapeutic Gene Delivery Across the Endothelial Barrier
Project timeline: 9/20/2018 – 6/30/22
Direct Costs: $1,643,022
Indirect Costs: $907,968
Type of Grant: R01

 

PI: Lori Birder, Division of Renal-Electrolyte
Agency: NIDDK
Title: Contribution of Stress Induced Autonomic and Urothelial Dysregulation to IC/BPS
Project timeline: 8/20/2018 – 5/31/2023
Direct Costs: $2,863,256
Indirect Costs: $660,111
Type of Grant: R01

 

PI: Alison Morris, MD, MS, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Systems Biology of Diffusion Impairment in HIV
Project timeline: 8/1/2018 – 5/31/2022
Direct Costs: $1,998,172
Indirect Costs: $1,103,987
Type of Grant: R01

 

PI: Anuradha Ray, PhD, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Understanding Severe Asthma Using an Experimental Model
Project timeline: 8/1/2018 – 6/30/2022
Direct Costs: $1,264,844
Indirect Costs: $714,636
Type of Grant: R01

 

PI: Yuan Liu, PhD, Aging Institute
Agency: NHLBI
Title: DCAF7/HDAC4/TFEB Axis in Acute Lung Injury
Project timeline: 8/1/2018 – 5/31/2023
Direct Costs: $1,503,255
Indirect Costs: $855,075
Type of Grant: R01

 

PI: Toren Finkel, MD, PhD, Aging Institute
Agency: NHLBI
Title: Vascular Autophagy as a Mediator of Vascular Aging and Homeostasis
Project timeline: 8/1/2018 – 5/31/2022
Direct Costs: $1,430,508
Indirect Costs: $808,235
Type of Grant: R01

 

Alison Morris, MD, MS, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)
Project timeline: 8/15/2018 – 6/30/2023
Direct Costs: $1,611,856
Indirect Costs: $118,003
Type of Grant: K12

 

PI: Ramon Bataller, MD, PhD, Division of Gastroenterology, Hepatology, and Nutrition
Agency: NIAAA
Title: Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies
Project timeline: 8/1/2018 – 6/30/2023
Direct Costs: $1,140,072
Indirect Costs: $644,641
Type of Grant: (Collaborative U01)

 

PI: Jessica Merlin, MD, PhD, MBA, Division of General Internal Medicine
Agency: NIMH
Title: Evaluation of the Efficacy and Mechanism of a Novel Intervention for Chronic Pain Tailored to People Living with HIV
Project timeline: 7/18/2018 – 4/30/2023
Direct Costs: $2,669,868
Indirect Costs: $390,263
Type of Grant: R01

 

PI: Ann Marie M. Rosland, MD, MS, Division of General Internal Medicine
Agency: NIDDK
Title: Comparative Effectiveness of Adding Family Supporter Training and Engagement to a CHW-Led Intervention to Improve Behavioral Management of Multiple Risk Factors for Diabetes Complications
Project timeline: 7/25/18 -- 6/30/2023
Direct Costs: $2,361,465
Indirect Costs: $192,125
Type of Grant: R01

 

PI: Johnathan Alder, PhD, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Mechanisms of Telomere-Mediated Lung Disease
Project timeline: 7/1/2018 – 6/30/2023
Direct Costs: $1,282,875
Indirect Costs: $583,575
Type of Grant: R01

 

PI: Marc Simon, MD, Division of Cardiology
Agency: NIA
Title: A Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction
Project timeline: 5/1/2018 – 2/23/2023
Direct Costs: $2,039,638
Indirect Costs: $1,125,506
Type of Grant: R01

 

PI: Partha Dutta, DVM, PhD, Division of Cardiology
Agency: NHLBI
Title: Mechanisms of Myocardial Infarction-Induced Insulin Resistance
Project timeline: 4/2/2018 – 2/28/2013
Direct Costs: $1,671,902
Indirect Costs: $922,777
Type of Grant: R01

 

PI: Lori Birder, Division of Renal-Electrolyte
Agency: NIA
Title: Bladder Mucosal Dysfunction During Aging
Project timeline: 4/1/2018 – 3/31/2023
Direct Costs: $1,789,580
Indirect Costs: $824,356
Type of Grant: R01

 

PI: Janet S. Lee, MD, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Host Control Mechanisms Against K. Pneumoniae Infection in the Lungs
Project timeline: 4/1/2018 – 3/31/2022
Direct Costs: $1,000,000
Indirect Costs: $564,376

 

PI: Brian Primack, MD, PhD, Division of General Internal Medicine
Agency: NCI
Title: Leveraging Twitter to Monitor Nicotine and Tobacco Related Cancer Communication
Project timeline: 3/1/2018 – 2/28/2022
Direct Costs: $1,292,018
Indirect Costs: $632,493
Type of Grant: R01

 

PI: Kevin Kraemer, MD, MSc, Division of General Internal Medicine
Agency: PCORI
Title: Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Non-Cancer Pain in Primary Care
Project timeline: 2/1/2018 – 1/31/2022
Direct Costs: $3,193,423
Indirect Costs: $779,394
Type of Grant: RES

 

PI: Beibei Chen, PhD, Aging Institute
Agency: NHLBI
Title: Systematic Investigation of Protein Ubiquitination in ARDS
Project timeline: 1/26/2018 – 11/30/2024
Direct Costs: $4,064,135
Indirect Costs: $2,292,561
Type of Grant: R35

 

PI: Galen Switzer, PhD, Division of General Internal Medicine
Agency: NHLBI
Title: Health-Related Quality of Life Among Pediatric Hematopoietic Stem Cell Disorders
Project timeline: 1/6/2018 – 12/31/2021
Direct Costs: $2,240,086
Indirect Costs: $652,246
Type of Grant: R01

 

PI: Robert Lafyatis, Division of Rheumatology and Immunology
Agency: NIAMS
Title: Translational Studies for Identifying and Targeting Novel Pathways in Systemic Sclerosis Pathogenesis
Project timeline: 9/22/2017 – 8/31/2022
Direct Costs: $4,896,169
Indirect Costs: $1,624,050
Type of Grant: P50

 

PI: David Binion, MD, Division of Gastroenterology, Hepatology, and Nutrition
Agency: DOD
Title: Utilizing Clinical Metadata to Predict High-cost Complications and Treatment Response in IBD:  Development of Clinical Decision Support Tools
Project timeline: 9/1/17 – 8/31/20
Direct Costs: $1,707,135
Indirect Costs: $876,433
Type of Grant: RES

 

PI: David C. Whitcomb, MD, PhD, Division of Gastroenterology, Hepatology, and Nutrition
Agency: DOD
Title: Mechanism of Systemic Inflammation-Associated Endothelial and Epithelial Cell Dysfunction Following Acute Pancreatitis, Trauma and Burns
Project timeline: 9/1/2017 – 8/31/2020
Direct Costs: $1,186,732
Indirect Costs: $636,359
Type of Grant: RES

 

PI: John F. McDyer, MD, Division of Pulmonary, Allergy, and Critical Care Medicine
Agency: NHLBI
Title: Role of F-Box Proteins in Lung Transplantation
Project timeline: 7/15/2017 – 4/30/21
Direct Costs: $1,374,568
Indirect Costs: $765,062
Type of Grant: R01