Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

Faculty Profiles
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photo Barbara Methé, PhD

Pulmonary, Allergy and Critical Care Medicine

Professor of Medicine

Co-director for Basic Science, Center for Microbiome and Medicine

Email: metheba@upmc.edu

Phone: 412-648-7784
Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-648-7784
Fax: 412-624-8373
E-mail: metheba@upmc.edu
Administrative Assistant:
Cindy Vinkovich
Email: vinkovichc@upmc.edu
Phone: 412-648-7784
Fax: 412-624-8373
Education and Training
Education
BS, The University at Albany
MS, Environmental Engineering, Rensselaer Polytechnic Institute, 1993
PhD, Environmental Engineering, Rensselaer Polytechnic Institute, 1998
Research Interest
Dr. Methé's research focuses on microbial ecology and the relationship of the microbiome to lung disease.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Tarabichi, Y, Li, K, Hu, S, Nguyen, C, Wang, X, Elashoff, D, Saira, K, Frank, B, Bihan, M, Ghedin, E, Deng, JC, Methe, BA. The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles. Microbiome. 2015; Dec 15;3(1): 74.
Strange, C, Senior, RM, Sciurba, F, O'Neal, S, Morris, A, Wisniewski, SR, Bowler, R, Hochheiser, HS, Becich, MJ, Zhang, Y, Leader, JK, Methe, BA, Kaminski, N, Sandhaus, RA. GRADS Alpha-1 Study Group. Rationale and design of the genomic research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc. 2015; Oct;12(10): 1551-60.
McCorrison, JM, Venepally, P, Singh, I, Fouts, DE, Lasken, RS, Methe, BA. NeatFreq: Reference-free data reduction and coverage normalization for de novo sequence assembly. BMC Bioinformatics. 2014; 15: 357.
Alekseyenko, AV, Perez-Perez, GI, De Souza, A, Strober, B, Gao, Z, Bihan, M, Li, K, Methe, BA, Blaser, MJ. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013; Dec 23;1(1): 31.
Methe, BA, Lasa, I. Microbiology in the 'omics era: from the study of single cells to communities and beyond. Curr Opin Microbiol. 2013; Oct;16(5): 602-4.
Li, K, Bihan, M, Methe, BA. Analyses of the stability and core taxonomic memberships of the human microbiome. PLoS One. 2013; May 6;8(5): e63139.
Conlon, EM, Postier, BL, Methe, BA, Nevin, KP, Lovely, DR. A Bayesian model for pooling gene expression studies that incorporates co-regulation information. PLoS One. 2012; 7(12): e52137.
Sponsored Research/Activities
Title: Artificial Intelligence (AI) in Gut Microbiome
Role: Principal Investigator
Funding Agency: University of Pittsburgh Medical Center
Start Year: 2020
End Year: 2020
Title: An integrated platform for investigating metformin-derived alterations of the microbial metabolome to improve healthy aging
Role: Principal Investigator
Funding Agency: UPMC Enterprises
Grant Number: IND AGR
Start Year: 2019
End Year: 2021
Title: Determination of Immunogenic Microbiota in the Lung: Leveraging the Lung HIV Microbiome Project
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R21 HL143091
Start Year: 2018
End Year: 2020
Title: PITTSBURGH OLDER AMERICANS INDEPENDENCE CENTER
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2020
End Year: 2025
Title: Feasibility of Studying Microbiome in Frozen Saliva and Formalin-Fixed Colon in PD Using Systemic Synuclein Sampling Study (S4) Samples
Role: Co-Investigator
Funding Agency: Michael J. Fox Foundation
Grant Number: RES
Start Year: 2020
End Year: 2020
Title: Mechanisms of maternal Immunoglobulin A control over the neonatal microbiota and the development of Necrotizing Enterocolitis.
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK120697
Start Year: 2019
End Year: 2024
Title: Fecal Microbiota Transplant and Immune Checkpoint Blockade in Melanoma
Role: Co-Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA222203
Start Year: 2018
End Year: 2023
Title: Systems Biology of Diffusion Impairment in HIV
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL140963
Start Year: 2018
End Year: 2022
Title: Impact of Virome on Microbial Communities in the Respiratory Tract
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R61 HL137077
Start Year: 2017
End Year: 2022
Title: Dysbiosis Impact on Lung Disease in HIV (DimpL) Study
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL138630
Start Year: 2017
End Year: 2021
Title: CAREER: Microbial contributions to host phenotypic flexibility
Role: Biostatistician
Funding Agency: National Science Foundation
Grant Number: RES
Start Year: 2020
End Year: 2025

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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