Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine

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photo Matthew R. Pipeling, MD

Assistant Professor of Medicine


Phone: 412-647-8477

Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-647-8477
Fax: 412-692-2260
Administrative Assistant:
M. Sharon Droppa
Phone: 412-647-8477
Fax: 412-692-2260
Education and Training
BS, Biological Sciences, University of Maryland, 1998
MD, Johns Hopkins Hospital, 2003
Residency, Internal Medicine, Johns Hopkins Hospital, 2006
Fellowship, Pulmonary and Critical Care, Johns Hopkins Hospital, 2010
Research Interest
• Assessment of CMV-specific cell-mediated immunity to allow risk stratification of lung transplant recipients and potentially guide clinical management with regards to CMV viremia and disease

• Post-transplant lymphoproliferative disorder (PTLD)- assessment of risk factors, therapeutic options and efficacy, relationship to EBV-specific immunity

• Thrombotic Thrombocytopenic Purpura (TTP)- association with calcineurin inhibitor-based immunosuppression and allograft outcomes with the use of calcineurin inhibitor-free immunosuppression.
For my complete bibliography, Click Here.
Selected Publications:
Popescu, I, Pipeling, MR, Mannem, H, Shah, PD, Orens, JB, Connors, M, Migueles, SA, McDyer, JF. IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. J Immunol. 2016; Jan 15;196(2): 877-90.
Shah, PD, Zhong, Q, Lendermon, EA, Pipeling, MR, McDyer, JF. Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis. Viral Immunol. 2015; 28(5): 255-64.
Popescu, I, Pipeling, M, Akulian, J, McDyer, J. Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. Methods Mol Biol. 2014; 1186: 21-47.
Morrell, MR, Pilewski, JM, Gries, CJ, Pipeling, MR, Crespo, MM, Ensor, CR, Yousem, SA, D'Cunha, J, Shigemura, N, Bermudez, CA, McDyer, JF, Zeevi, A. De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation. J Heart Lung Transplant. 2014; 33(12): 1288-94.
Popescu, I, Pipeling, M, Shah, PD, Orens, JB, McDyer, FJ. Eomesodermin balance, effector function and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control. J Immunol. 2014; 193(11): 5709-22.
Pipeling, MR, Fan, E. Therapies for refractory hypoxemia in acute respiratory distress syndrome. JAMA. 2010; 304(22): 2521-2527.
Pipeling, M, West, EE, Osborne, CM, Whitlock, AB, Dropulic, LK, Willett, MH, Forman, M, Valsamakis, A, Orens, JB, Moller, DR, Lechtzin, N, Migueles, SA, Connors, M, McDyer, JF. Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. J Immunol. 2008; 181(1): 546-556.