Department of Medicine

University of Pittsburgh

Mandy McGeachy, PhD

photo

Assistant Professor of Medicine

Office: 3500 Terrace Street
BST South, S719
Pittsburgh, PA 15261
 
Phone: 412-648-1587
Fax: 412-383-8864
E-mail: mmcgeach@pitt.edu

Education
BSc, University of Glasgow, Scotland, UK, 2001
PhD, University of Edinburgh, Scotland, UK, 2005
Postdoc, Schering-Plough Biopharma/DNAX, 2009

Area of Specialization/Research Interest  
Autoimmunity and chronic inflammatory disease
Activation and regulation of Th17 cells
IL-23 and other cytokines that modulate inflammation
In vivo modeling of human autoimmune disease such as multiple sclerosis, arthritis, colitis
 

Profile
The McGeachy lab aims to understand the mechanisms behind inflammatory autoimmune diseases such as arthritis, multiple sclerosis and colitis. Th17 cells are implicated in driving these diseases, and the McGeachy lab investigates the mechanisms through which Th17 cells are activated and regulated, and how these impact disease pathogenesis in various tissues. We have a particular focus on the functions of the cytokine IL-23 in promoting Th17-mediated inflammation, as IL-23 has been found to be a key driver of Th17 cells in both mouse models and human disease."

Recent Grants
Title: B-cell Depletion Therapy with Rituximab for Thyroid Eye Disease (BetTeR TED)
Role: University of Pittsburgh’s CTSI
Funding Agency: Co-PI
Start Year: 2014
End Year: 2015
Title: Regulation of Th17 Autoimmune CNS Inflammation
Role: PI
Funding Agency: NIH/NIAID
Start Year: 2014
End Year: 2015
Title: STAT3/IL-23-Driven Oral Immune Responses to Candida albicans
Role: Co-Investigator
Funding Agency: NIH/NIAID
Start Year: 2013
End Year: 2017
Title: IL-17 Receptor Signaling in the Oral Mucosa
Role: Co-Investigator
Funding Agency: NIH/NIAID
Start Year: 2013
End Year: 2017
Title: Identification of the PBMC gene signature that predicts response to tofacitinib or etanercept in RA
Role: PI
Funding Agency: Pfizer ASPIRE award
Start Year: 2013
End Year: 2015
Title: A Novel Integrin expressed by Th17 Cells in RA
Role: PI
Funding Agency: Rheumatology Research Foundation Disease Targeted Research grant
Start Year: 2013
End Year: 2014
Title: Development of lentiviral gene expression and knockdown systems to dissect role of IL-23 specific genes in Th17 pathogenesis
Role: PI
Funding Agency: Competitive Medical Research Fund award
Start Year: 2013
End Year: 2015
Title: Identifying the IL-23 Driven markers of Th17 Pathogenesis in Rheumatoid Arthritis Patients
Role: PI
Funding Agency: BD Biosciences Immunology Research Award
Start Year: 2012
End Year: 2014
Title: Rheumatoid Arthritis Comparative Effectiveness Research (RACER)
Role: Co-Investigator
Funding Agency: Genentech, Inc.
Start Year: 2010
End Year: 2015

Recent Peer-Reviewed Publications
Title: Rheumatoid Arthritis Patients Exhibit Impaired Candida-albican specific Th17 responses
Author(s): S Bishu, EW Su, ER Wilkerson, KA Reckley, DM Jones, MJ McGeachy, SL Gaffen, MC Levesque
Year: 2014
Journal: Arthritis Research and Therapy
Volume: 16(1)
Page(s): R50
Title: Autoimmune Th17 Memory Cell Function and Expansion are Dependent on IL-23
Author(s): CJ Haines, Y Chen, WM Blumenschein, ..., MJ McGeachy
Year: 2013
Journal: Cell Reports
Volume: 3(5)
Page(s): 1378-1388
Title: Th17 Memory cells aren’t fooled by sugar coating
Author(s): MJ McGeachy
Year: 2011
Journal: Immunity
Volume: 35(6)
Page(s): 854-856
Title: GM-CSF: the secret weapon in the T(H)17 arsenal
Author(s): MJ McGeachy
Year: 2011
Journal: Nature Immunology
Volume: 12(6)
Page(s): 521-522
Title: Foxp3+ Regulatory T cells Promote Th17 Development in vivo
Author(s): Y Chen, K Hochweller, C Haines, WB Blumenschein, T McClanahan, G Hamerling, DJ Cua, MJ McGeachy
Year: 2011
Journal: Immunity
Volume: 34(3)
Page(s): 409-421
Title: Interleukin-23 Drives Intestinal Inflammation Through Direct Activity on T Cells
Author(s): PP Ahern, C Schiering, S Buonocore, MJ McGeachy, DJ Cua, KJ Maloy, F Powrie
Year: 2010
Journal: Immunity
Volume: 33(2)
Page(s): 279-288
Title: Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage
Author(s): K Boniface, WM Blumenschein, K Brovont-Porth, MJ McGeachy, B Basham, ..., R de Waal Malefyt
Year: 2010
Journal: Journal of Immunology
Volume: 185(1)
Page(s): 679-687
Title: Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic-AMP and EP2/EP4 receptor signaling
Author(s): K Boniface, S Kristian, S Bak-Jensen, ..., MJ McGeachy, ..., R de Waal Malefyt
Year: 2009
Journal: Journal of Experimental Medicine
Volume: 206(3)
Page(s): 535-548
Title: Th17 cell differentiation: the long and winding road
Author(s): MJ McGeachy, DJ Cua
Year: 2008
Journal: Immunity
Volume: 28(4)
Page(s): 445-453
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