Department of Medicine

University of Pittsburgh

Division of Pulmonary, Allergy, and Critical Care Medicine
3459 Fifth Avenue,
628 NW
Pittsburgh, PA 15213
Academic Office: (412) 692-2210
Comprehensive Lung Center (Patient Care and Referral): (412) 648-6161

Carol Feghali-Bostwick, PhD

Dr. Feghali-Bostwick

Associate Professor of Medicine and Pathology
NW628 Montefiore Hospital
3459 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-624-7225
Fax: 412-624-1670
Email: feghali2@pitt.edu
Assistant: Terri Heinrich
Assistant Email: heinrichta@upmc.edu

Bio

Dr. Feghali-Bostwick is a graduate of the American University of Beirut, receiving both her bachelor’s and master’s degrees, and Tulane University, where she received her Ph.D. in Microbiology and Immunology. She completed post-graduate fellowship training in the Division of Rheumatology and Clinical Immunology at the University of Pittsburgh.

Academic and Research Interests

Dr. Feghali-Bostwick’s laboratory focuses on identifying the role of insulin-like growth factor binding proteins in aberrant extracellular matrix production in Systemic Sclerosis (Scleroderma) and Idiopathic Pulmonary Fibrosis, in the development of dermal and pulmonary fibrosis. Current members of the laboratory are exploring mechanisms mediating the development, progression, and perpetuation of fibrosis. Dr. Feghali-Bostwick is also conducting a study on twins with Scleroderma to delineate the role of environmental and genetic factors in the development of the disease.

puzzle Fibrosis Fibrosis skin Immune cells Lung Fibroblasts Genes Autoantibodies cytokines Enivironment Growth Factors Extracellular Matrix

Key Publications

Yamaguchi Y, Takihara T, Chambers RA, Veraldi KL, Larregina AT and Feghali-Bostwick CA. A Peptide Derived from Endostatin Ameliorates Organ Fibrosis. Sci Transl Med 30 May 2012: Vol. 4, Issue 136, p. 136ra71 Sci. Transl. Med. DOI: 10.1126/scitranslmed.3003421

E Hsu and Feghali-Bostwick CA. Insulin-Like Growth Factor-II Is Increased in Systemic Sclerosis-Associated Pulmonary Fibrosis and Contributes to the Fibrotic Process via Jun N-Terminal Kinase- and Phosphatidylinositol-3 Kinase-Dependent Pathways. American Journal of Pathology. 2008;172:1580-1590

Yasuoka H, Zhou Z, Pilewski JM, Oury TD, Choi AMK and Feghali-Bostwick CA.  Insulin-Like Growth Factor-Binding Protein-5 Induces Pulmonary Fibrosis and Triggers Mononuclear Cellular Infiltration.  American Journal of Pathology. 2006;169:1633-1642

Feghali-Bostwick C, Medsger TA Jr, Wright TM. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum. 2003 Jul;48(7):1956-63.

PubMed Link

News

Dr. Feghali-Bostwick is featured in the newsletter of the Scleroderma Foundation here and here. She serves on the Board of Directors for this Foundation.