Unpublished - Please do no download unless authorized by Dr Naftali Kaminski


Network Analysis of Temporal Effects of Intermittent- (IH) and Sustained Hypoxia (SH) on Rat Lungs

W. Wu, N.B. Dave, P.J. Strollo, E. Kovkarova-Naumovski, S.W. Ryter, S.R. Reeves, E. Dayyat, Y. Wang, A.M.K. Choi, D. Gozal, N. Kaminski, submitted to Physiological Genomics.

  The LRSA software           Differentially Expressed Genes in IH            Differentially Expressed Genes in SH          


In this paper, we have studied temporal  effects of intermittent- and sustained hypoxia on rat lungs using gene expression data. In order to analyze these data, we have developed the LRSA software for estimating differentially expressed genes and discovering their temporal expression patterns in the time-series data. The software is available to use here. You can also find lists of genes that are differentially expressed in either IH or SH.


 


Relevant University of Pittsburgh links:

Lung Translational Genomics Center

Dorothy and P. Richard P.  Simmons for Interstitial Lung Disease

Division of Pulmonary, Allergy and Critical Care Medicine

University of Pittsburgh Genomics and Proteomics Core