Department of Medicine

University of Pittsburgh

Deborah L. Galson, PhD

photo

Associate Professor of Medicine, Division of Hematology/Oncology

Associate Professor of Microbiology & Molecular Genetics

Member, UPCI

Member, Molecular and Cellular Cancer Biology Program

Director, Pittsburgh Center for Bone & Mineral Research

Office: Hillman Cancer Center Research Pavilion, Rm 1.19b
5117 Centre Avenue
Pittsburgh, PA 15213
 
Phone: 412-623-1112
Fax: 412-623-1415
E-mail: galson@pitt.edu

Education
Ph.D., Brandeis University, 1984
B.S., Cornell University, 1976

Training
Postdoctoral, Massachusetts Institute of Technology, 1990
Instructor, Harvard Medical School/Brigham & Women's Hospital, 1995

Area of Specialization/Research Interest  
Regulation of Osteoclast Differentiation
Regulation of Osteoblast Differentiation
Multiple Myeloma Bone Disease
Paget's Disease of Bone
Signal Transduction & Transcription Regulation
Measles virus nucleoprotein (MVNP) and p62 (SQSTM1) mutations in Paget's
Gfi1 Repression of Osteoblast Differentiation in MM
TBK1, IKKe, & Optineurin
Chromatin modification
NFATc1, NF-kB, Spi-1/PU.1, C/EBPß, ATF4, ATF7, TAF12
 

Profile
The main theme of my research has been to investigate the regulation of differentiation starting from identifying the key transcriptional regulators outwards to reveal the important signal transduction pathways. To reveal regulatory mechanisms that underlie the concerted activation of osteoclast-specific genes during differentiation, we utilized the calcitonin receptor gene as a model system. We thus identified that NFATc1 plays a significant role in osteoclastogenesis. Our current studies focus on: 1) the mechanism by which Measles virus nucleocapsid protein, which contributes to Paget’s disease of bone, activates cellular genes and alters osteoclast differentiation; 2) the mechanism of cooperation between MVNP and p62 with pagetic mutations (eg. p62P392L) to generate Paget's lesions; 3) the mechanism by which multiple myeloma suppresses osteoblast differentiation; 4) the role of Gfi1 in regulating osteoblast and osteoclast differentiation; 5) the role of ATF4 in osteoclastogenesis and angiogenesis in bone; 6) Regulation of the IL1B gene.

Lab Personnel and Web page
Juraj Adamik, PhD, Benedicte Sammut, PhD, Quanhong Sun, PhD Peng Zhang, MD, PhD
Recent Grants
Title: Mechanisms of Myeloma Cell Regulation of Gfi1 Function in BMSC
Role: PI
Amount: 425,926
Funding Agency: Commonwealth of PA
Start Year: 2013
End Year: 2014
Title: ATF4 and Osteoclastogenesis
Role: Co-Investigator
Amount: $1,132,200
Funding Agency: NIH/NIAMS
Start Year: 2010
End Year: 2012
Title: GFI-1 and Osteoblast Suppression in Multiple Myeloma
Role: PI
Amount: $1,451,543
Funding Agency: NIH/NIAMS
Start Year: 2010
End Year: 2015
Title: Viral and Genetic Regulation of Abnormal OCL Activity in PD (Paget's Disease)
Role: PI
Amount: $1,636,300
Funding Agency: NIH/NIAMS
Start Year: 2008
End Year: 2014

Recent Peer-Reviewed Publications
Title: Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling
Author(s): Wang F-M, Sarmasik A, Hiruma Y, Sun Q, Sammut B, Windle JJ, Roodman GD, Galson DL
Year: 2013
Journal: Bone
Volume: 53
Page(s): 269-76
Title: TBK1 mediates critical effects of Measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation
Author(s): Sun Q, Sammut B, Wang F-M, Kurihara N, Windle JJ, Roodman GD, Galson DL
Year: 2013
Journal: J Bone Miner Res
Volume: in press June 10
Page(s): Epub2013June21
Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget’s disease
Author(s): Teramachi J, Hiruma Y, Ishizuka S, Ishizuka H, Brown JP, Michou L, Cao H, Galson DL, Subler MA, Zhou H, Dempster DW, Windle JJ, Roodman GD, Kurihara N
Year: 2013
Journal: J Bone Miner Res
Volume: 28
Page(s): 1489-500
Title: Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1ß and Tumor Necrosis Factor alpha
Author(s): Adamik J, Wang KZ, Unlu S, Su A-J, Tannahill GM, Galson DL, O’Neill LA, Auron PE
Year: 2013
Journal: PLoS One
Volume: in press June 19
Page(s):
Title: ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment
Author(s): Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im H-J, Chen D, Xiao G
Year: 2013
Journal: J Bone Miner Res:
Volume: in press Apr 2
Page(s): Epub2013May3
Title: Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment
Author(s): D’Souza S, Kurihara N, Shiozawa Y, Joseph J, Taichman RS, Galson DL, Roodman GD
Year: 2012
Journal: Blood
Volume: 119
Page(s): 1888-96
Title: Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses the pro-survival XBP1 signaling in human multiple myeloma cells
Author(s): Wang F-M, Galson DL, Roodman GD, Ouyang H
Year: 2011
Journal: Exp Hematology
Volume: 39
Page(s): 999-1006
Title: IMiD® immunomodulatory compounds block C/EBPß translation through eIF4E downregulation resulting in inhibition of multiple myeloma
Author(s): Li S, Pal R, Monaghan SA, Schafer P, Ouyang H, Mapara M, Galson DL, Lentzsch S
Year: 2011
Journal: Blood
Volume: 117
Page(s): 5157-65
Title: Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
Author(s): D’Souza S, Del Prete D, Jin S, Sun Q, Huston, AJ, Kostov FE, Sammut B, Hong, C-S, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL
Year: 2011
Journal: Blood
Volume: 118
Page(s): 6871-80
Title: Contributions of the Measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to Paget’s disease
Author(s): Kurihara N, Hiruma Y, Yamana K, Michou L, Rousseau C, Morissette J, Galson DL, Zhou H, Dempster DW, Windle JJ, Brown JP, Roodman GD
Year: 2011
Journal: Cell Metabolism
Volume: 13
Page(s): 23-34.
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