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My major research interests revolve around the molecular biology of Acute Promyelocytic Leukemia. My laboratory was the first to clone the t(5;17) variant of APL, and to identify the translocation as fusing nucleophosmin to the retinoic acid receptor alpha. We have been actively investigating the function of the resultant fusion protein, with an eye towards the mechanism underlying APL. My clinical interests reside in both malignant and non-malignant hematology, particularly the acute leukemias. I am involved in clinical protocols addressing issues in the treatment of myelodysplastic syndrome, AML, and ITP. From an administrative standpoint, I am Program Director for the ACGME-accredited Hematology/Oncology Fellowship Program.
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