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Department of Medicine

  Division of Hematology/Oncology

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photo Solomon F Ofori-Acquah, PhD

Associate Professor of Medicine, Division of Hematology/Oncology

Director, Center for Translational and International Hematology

Heart, Lung, Blood and Vascular Medicine Institute

Email: sfo2@pitt.edu

Phone: 412-648-9231

Contact
Office: 200 Lothrop Street
BST 1252
Pittsburgh, PA 15261
 
Phone: 412-648-9231
Fax:
E-mail: sfo2@pitt.edu
Education and Training
Education
PhD, University of London, King's College School of Medicine and Denstistry, 1999
MSc, University of London, Birkbeck College, 1992
Training
Postdoctoral Fellowship, Sickle Cell Scholar, University of South Alabama, 2000
Pediatric Executive Program, Emory University School of Medicine, 2008
Research Interest
Dr. Ofori-Acquah has a research interest in molecular hematology, endothelial barrier function, sickle cell disease (SCD) and global health. His basic science research is on mechanisms of neutralizing erythroid danger associated molecular pattern (eDAMP) molecules. This work encompasses studies of developmental, genetic and epigenetic regulation of hemopexin and heme oxygenase-1, the key neutralizing molecules of extracellular heme the prototypical eDAMP. His basic research is translated to understanding the role and mechanism of extracellular heme in the pathobiology of vascular complications in SCD. A major translational focus is acute chest syndrome, the leading cause of premature death in SCD. The Ofori-Acquah lab developed the first mouse model of acute chest syndrome. This preclinical model is currently being used to find targeted therapies for acute chest syndrome. His global health research is centered on a longitudinal observational study of a large newborn cohort in Ghana to define markers of end-organ damage in SCD. Additional global health work focused also on SCD is performed under the auspices of the H3Africa consortium with a multi-disciplinary team of collaborators in Cameroon, Tanzania and South Africa. Dr. Ofori-Acquah directs a research education NIH funded R25 program aimed at catalyzing the training of graduates, postdocs and junior faculty in blood science research. He is Visiting Professor and Director of a Human Genetics graduate course in a Wellcome Trust funded DELTAS (Developing Excellence in Leadership, Training and Science) program at the University of Ghana in collaboration with the Pitt Graduate School of Public Health.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bean CJ, Boulet SL, Ellingsen D, Pyle ME, Barron-Casella EA, Casella JF, Payne AB, Driggers J, Trau HA, Yang G, Jones K, Ofori-Acquah SF, Hooper WC, DeBaun MR. Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease. Blood. 2012; 120(18): 3822-3828.
Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitainik SL, Zimring JC. Alloimunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. Transfusion,. Transfusion. 2012; 52(2): 231-240.
Tan F, Monsujac M, Adams AL, Adabe B, Taye O, Rizzo M, Ofori-Acuqah SF. Enhanced down-regulation of ALCAM/CD166 in African American Breast Cancer. BMC Cancer. 2014; 14: 715.
Gladwin MT, Ofori-Acquah SF. Erythroid DAMPs drive inflammation in SCD. Blood. 2014; 123(24): 3689-3690.
Ofori-Acquah SF, King JA. Activated leukocyte cell adhesion molecule: a new paradox in cancer. Translational Research. 2008; 151(3): 122-128.
Ofori-Acquah F, Lalloz MR, Layton DM. Nucleotide variation regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region. Blood Cells, Molecules and Diseases. 2001; 27(5): 803-811.
Owusu-Ansah A, Ihunnah CA, Walker AL, Ofori-Acquah SF. Inflammatory targets of therapy in sickle cell disease. Translational Research. 2016; 167(1): 281-297.
H3Africa Consortium, Rotimi C, Abayomi A, Ofoi-Acquah SF, et al. Research capacity. Enabling the genomic revolution in Africa. Science. 2014; 344(6190): 1346-1348.
Adisa OA, Hu Y, Ghosh S, Aryee D, Osunkwo I, Ofori-Acquah SF. Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. British Journal of Haematology. 2013; 162(5): 702-705.
Osunkwo I, Ziegler TR, Alvarez J, McCrackern C, Cherry K, Osunkwo CE, Ofori-Acquah SF, Ghosh S, Ogunbobode A, Rhodes J, Eckman JR, Dampier C, Tangpricha V. High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study. British Journal of Haematology. 2012; 159(2): 211-215.
Sponsored Research/Activities
Title: Heme-Oxygenase-1 Infusion Therapy for Sickle Cell Disease
Role: Principal Investigator
Funding Agency: Shire
Grant Number: RES
Start Year: 2017
End Year: 2019
Title: Pittsburgh Intensive Training in Hematology Research (PITHR)
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R25 HL128640
Start Year: 2015
End Year: 2020
Title: Preclinical Efficacy of Sanguinate in Acute Chest Syndrome: A Pilot Study
Role: Principal Investigator
Funding Agency: Prolong Pharmaceuticals
Start Year: 2015
End Year: 2016
Title: Mechanisms of Endothelial Barrier Phenotypes in Sickle Cell Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL106192
Start Year: 2011
End Year: 2016
Title: Pittsburgh Undergraduate Research Diversity Program (PURDIP)
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R25 HL130600
Start Year: 2016
End Year: 2019
Title: Role of Erythroid DAMP Molecules in the Pathogenesis of Vascular Injury in Sepsis
Role: Co-Principal Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM113816
Start Year: 2015
End Year: 2019
Title: Role of Erythroid DAMP Molecules in the Pathogenesis of Vascular Injury in Sepsis
Role: Co-Principal Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM113816
Start Year: 2015
End Year: 2019
Title: Pulmonary Arteriole Occlusion by Platelet-Neutrophil Micro-Emboli in Acute Chest Syndrome
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2015
End Year: 2020
Title: Hemostasis and Vascular Biology Research Institute - Ofori-Acquah
Role: Co-Investigator
Funding Agency: Hemophilia Center of Western PA
Start Year: 2013
End Year: 2018
Title: Cellular and Molecular Mechanisms of Acute Lung Injury in Sickle Cell Disease (Research)
Role: Co-Investigator
Funding Agency: Emory University/National Heart, Lung, & Blood Institute
Grant Number: U01 HL117721
Start Year: 2013
End Year: 2018
Title: Cellular and Molecular Mechanisms of Acute Lung Injury in Sickle Cell Disease (Translational)
Role: Co-Investigator
Funding Agency: Emory University/National Heart, Lung, & Blood Institute
Grant Number: U01 HL117721
Start Year: 2013
End Year: 2018
Notable Achievements
Young Investigator of the Year, British Society for Hematology, 1997
Traveling Research Fellow, Wellcome Trust UK, 2000
Center Scholar, University of South Alabama Comprehensive Sickle Cell Center, 2000-2003
Carl Storm Underrepresented Minority Fellow, Gordon Research Conference, 2005
Scholar, Vascular Medicine Institute, University of Pittsburgh, 1997