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Department of Medicine

Department of Medicine

  Division of Gastroenterology, Hepatology and Nutrition

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photo David C. Whitcomb, MD, PhD

Giant Eagle Foundation Professor of Cancer Genetics

Professor of Medicine, Cell Biology & Physiology and Human Genetics

Division of Gastroenterology, Hepatology and Nutrition

Director, UPMC Precision Medicine Service

Editor-in-Chief, Clinical and Translational Gastroenterology.

Email: whitcomb@pitt.edu

Phone: 412-578-9515

Contact
Office: Division of Gastroenterology, Hepatology and Nutrition
3708 Fifth Ave. - Medical Arts Bldg., 4th Floor
Pittsburgh, PA 15213
 
Phone: 412-578-9515
Fax: 412-578-9547
E-mail: whitcomb@pitt.edu
Administrative Assistant:
Diane Pochron
Address: Division of Gastroenterology, Hepatology & Nutrition
3708 5th Ave- Medical Arts Building, 4thFloor suite 401.5
Pittsburgh, PA 15213
Email: pochrond@pitt.edu
Phone: 412-578-9515
Fax: 412-578-9547
Education and Training
Education
BS, Manchester College - North Manchester, IN, 1978
MS - Physiology, Ohio State University - Columbus, OH, 1979
PhD - Physiology, Ohio State University - Columbus, OH, 1983
MD, Ohio State University - Columbus, OH, 1985
Training
Internship, Duke University - Durham, NC, 1986
Residency, Duke University - Durham, NC, 1988
Gastroenterology Fellowship, Duke University - Durham, NC, 1990
Research Interest
Dr. Whitcomb is a Professor of Medicine whose research program involves a pancreatic disease focus for modeling complex, multistep gene-environment interactive disorders requiring a precision medicine approach. Dr. Whitcomb's multicenter, genotype-phenotyping hereditary pancreatitis, and North American Pancreatitis Study II (NAPS2) programs, plus acute pancreatitis and pancreatic cancer studies using reverse engineering and predictive modeling approaches serve as a foundation and pathway for diseases in multiple organ systems. He leads the Genomic Resource to Enhance Available Therapy (GREAT) study, to initiate the delivery of precision medicine for complex chronic disorders and their complications. Dr Whitcomb also studies the pathophysiology of severe acute pancreatitis and pain genetics.
Clinical Interest
Acute pancreatitis, chronic pancreatitis, genetics, nutrition, and integration of genetics into clinical practice.
Educational Interest
PancreasFest (www.pancreasfest.com)
Publications
For my complete bibliography, Click Here.
Selected Publications:
Whitcomb DC, Frulloni L, Garg P, Greer JB, Schneider A, Yadav D, Shimosegawa T. Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition. Pancreatology. 2016; 16(2): 218-24.
Whitcomb DC, Bodhani A, Beckmann K, Sander-Struckmeier S, Liu S, Fuldeore M, Pollack PF, Khurmi RP. Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus. Pancreas. 2016; 45(5): 679-86.
LaRusch J, Lozano-Leon A, Stello K, Moore A, Muddana V, O'Connell M, Diergaarde B, Yadav D, Whitcomb DC. The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. Clin Transl Gastroenterol. 2015; 6: e68.
LaRusch J, Jung J, General IJ, Lewis MD, ..., Whitcomb DC & North American Pancreatits Study Group. Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis. Anderson MA, Banks PA, Conwell D, Lawrence C, Romagnuolo J, Baillie J, Alkaade S, Cote G, Gardner TB, Amann ST, Slivka A, Sandhu B, Aloe A, Kienholz ML, Yadav D, Barmada MM, Bahar I, Lee MG, Whitcomb DC; North American Pancreatitis Study Group. PLoS Genet. 2014; 10(7): e1004376.
Andersen DK, Andren-Sandberg A, Duell EJ, Goggins M, Korc M, Petersen GM, Smith JP, Whitcomb DC. Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. Pancreas. 2013; 42(8): 1227-37.
Whitcomb DC. What is personalized medicine and what should it replace?. Nat Rev Gastroenterol Hepatol. 2012; 9(7): 418-24.
Aoun E, Chang CC, Greer JB, Papachristou GI, Barmada MM, Whitcomb DC. Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis. PLoS One. 2008; 3(4): e2003.
Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996; 14(2): 141-5.
Sponsored Research/Activities
Title: Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK108306
Start Year: 2015
End Year: 2020
Title: PancreasFest2015: Applying Research Discoveries in pancreatitis & Pancreatic Cancer to Patient-Centered Care
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R13 DK107248
Start Year: 2015
End Year: 2016
Title: Evaluation of Pain in Chronic Pancreatitis using the NAPS2 Cohorts
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R21 DK098560
Start Year: 2014
End Year: 2017
Title: Acute Pancreatitis as a Model to Predict Transition of Systemic Inflammation to Organ Failure in Trauma and Critical Illness
Role: Principal Investigator
Funding Agency: Department of Defense
Start Year: 2014
End Year: 2017
Title: Employing Pharmacology in Human Disease Relevant Tissue to Support Pharmaceutical Discovery in Inflammatory Bowel Disease
Role: Co-Investigator
Funding Agency: Janssen Pharm
Start Year: 2014
End Year: 2016
Title: PancreasFest 2014: Risks and Mechanisms of Pancreatitis and Pancreatic Diabetes
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R13 DK103527
Start Year: 2014
End Year: 2015
Title: Genetics of Constant Pain in Chronic Pancreatitis
Role: Principal Investigator
Funding Agency: National Pancreas Foundation
Start Year: 2013
End Year: 2014
Title: Nutrition in Chronic Pancreatitis
Role: Co-Investigator
Funding Agency: Abbvie. Inc.
Start Year: 2012
End Year: 2016
Title: NAPS2-AS: Race-Dependent Risk for Pancreatitis
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK077906
Start Year: 2010
End Year: 2016
Title: Feeding and Pancreatic Rest in Acute Pancreatitis - Supplement
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK075803
Start Year: 2009
End Year: 2014
Title: Pancreatic Enzyme Supplements with Symptom Improvement and QOL
Role: Principal Investigator
Funding Agency: Solvay Pharmaceuticals
Grant Number: DRUG
Start Year: 2009
End Year: 2013
Title: Digestive Diseases Training Program
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK063922
Start Year: 2008
End Year: 2013
Notable Achievements
Fred B. Thomas Memorial Lecture, Internal Medicine Grand Rounds, The Ohio State University, Columbus Ohio, 2015
George E. Palade Medal for Lifetime Contributions to Pancreatic Research, the International Association of Pancreatology, Shanghai, China, 2015
Lifetime Achievement and Mentoring Award, Collaborative Alliance for Pancreatic Education and Research, 2015
David K Ginsberg MD Memorial Lecture, University of Pennsylvania, 2014
Frank R. Burton MD Memorial Lecture, Saint Louis University Medical Center Medicine Grand Rounds, 2014
The Andrea Gianaris Pancreatic Cancer Lectureship. Indiana University School of Medicine, 2013
The Berkowitz Distinguished Lecturer, Medicine Grand Rounds, Drexel University College of Medicine, 2012
Basil I Hirschowitz Visiting Professor Lectureship. University of Alabama at Birmingham, 2012
Weser Lectureship - “Pancreatitis and Personalized Medicine” UTHSCAS Medical Ground Rounds, University of Texas Health Science Center at San Antonio, 2012
Ranked as one of “20 Great Physicians in Pennsylvania”; Becker’s ACS Review, 2011