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photo Alison Morris, MD, MS

Pulmonary, Allergy and Critical Care Medicine

Professor of Medicine, Immunology, and Clinical and Translational Research

Director, Center for Medicine and the Microbiome

Vice Chair for Clinical Research, Department of Medicine

UPMC Chair in Translational Pulmonary and Critical Care Medicine

Email: morrisa@upmc.edu

Phone: 412-648-7784

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-648-7784
Fax: 412-692-2260
E-mail: morrisa@upmc.edu
Administrative Assistant:
Amy Flaugh
Email: flaughar@upmc.edu
Phone: 412-648-7784
Fax: 412-692-2260
Education and Training
Education
AB, Psychobiology, Harvard College, 1990
MD, Duke University, 1995
MS, Clinical Research, University of Pittsburgh, 2003
Training
Residency, Internal Medicine, University of California, San Francisco, 1997
Fellowship, Pulmonary and Critical Care, University of California, San Francisco, 2000
Fellowship, Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, 2002
Masters of Science, Clinical Research, University of Pittsburgh, 2003
Data Analytics, Heinz College, Carnegie Mellon University, 2015
Research Interest
Dr. Morris' research interests include HIV-associated lung disease as well as the role of the microbiome in disease. Her group works with large cohort epidemiologic studies of HIV and other diseases as well as in translational studies in which physiologic and molecular techniques are applied to patient populations. As part of her role in the Center for Medicine and the Microbiome, she works with collaborators in diverse areas studying the microbiome.

Dr. Morris’ research interests focus in several overlapping areas:
1. Role of the microbiome in HIV-associated lung disease
2. Understanding and manipulating the respiratory and gut microbiota in the ICU
3. The role of nitrate-reducing bacteria in pulmonary hypertension
2. HIV-associated emphysema and pulmonary hypertension
3. Role of Pneumocystis and other fungi in COPD and HIV
Clinical Interest
Dr. Morris’ clinical interests focus on lung disease in HIV-infected patients and in care of intensive care unit patients.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Segal LN, Clemente JC, Tsay JJ, Koralov SB, Keller BV, Wu BG, Yonghua L, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a TH17 phenotype. Nature Microbiology. 2016; 1: 16031.
Fitzpatrick, ME, Nouraie, M, Gingo, MR, Camp, D, Kessinger, CJ, Sincebaugh, JB, Clarke, A, Ries, JW, Kleerup, EC, Kingsley, L, Morris, A. Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons. AIDS. 2016; 30(9): 1327-39.
Cribbs, SK, Uppal, K, Li, S, Jones, DP, Huang, L, Tipton, L, Fitch, A, Greenblatt, RM, Kinglsey, L, Guidot, DM, Ghedin, E, Morris, A. Correlation of the lung microbiome with metabolic profiles in bronchoalveolar lavage fluid in HIV infection. Microbiome. 2016; 4: 3.
Cui, L., Lucht, L., Tipton, L., Rogers, M.B., Fitch, A., Kessinger, C., Camp, D., Kingsley, L,, Leo, N., Greenblatt, R.M., Fong, S., Stone, S., Dermand, J., Kleerup, E., Huang, L., Morris, A.*, Ghedin, E.*. Topographical diversity of the respiratory tract mycobiome and alteration in HIV and lung disease. American Journal of Respiratory and Critical Care Medicine. 2015; 191: 932-42.
Moller, DR, Koth, LL, Maier, LA, Morris, A, Drake, W, Rossman, M, Leader, JK, Collman, RG, Hamzeh, N, Sweiss, NJ, Zhang, Y, O'Neal, S, Senior, RM, Becich, M, Hochheiser, HS, Kaminski, N, Wisniewski, SR, Gibson, KF. GRADS Sarcoidosis Study Group. Rationale and design of the Genomic Research in Alpha-1 Antitrypsin and Sarcoidosis Study: Sarcoidosis Protocol. Annals of the American Thoracic Society. 2015; 12(10): 1561-71.
Fitzpatrick, ME, Gingo, MR, Kessinger, CJ, Lucht, L, Kleerup, E, Greenblatt, RM, Claman, D, Ponath, C, Fong, S, Huang, L, Morris, A. HIV infection is associated with diffusing capacity impairment in women. Journal of the Acquired Immunodeficiency Syndrome. 2013; 64(3): 284-8.
Morris, A, Beck, JM, Schloss, PD, Campbell, TB, Crothers, K, Curtis, JL, Flores, SC, Fontenot, AP, Ghedin, E, Huang, L, Jablonski, K, Kleerup, E, Lynch, SV, Sodergren, E, Twigg, H, Young, VB, Bassis, CM, Venkataraman, A, Schmidt, TM, Weinstock, GM. Comparison of the respiratory microbiome in healthy non-smokers and smokers. American Journal of Respiratory and Critical Care Medicine. 2013; 187(10): 1067-75.
Gingo, MR, George, MP, Kessinger, CJ, Lucht, L, Rissler, B, Weinman, R, Slivka, WA, McMahon, DK, Wenzel, SE, Sciurba, FC, Morris, A. Pulmonary function abnormalities in HIV-infected patients during the current antiretroviral therapy era. American Journal of Respiratory and Critical Care Medicine. 2010; 182(6): 790-6.
Morris, A, Kinglsey, LA, Groner, G, Lebedeva, IP, Beard, CB, Norris, KA. Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men. AIDS. 2004; 18(5): 793-8.
Sponsored Research/Activities
Title: Mentoring and Patient-Oriented Research in HIV Obstructive Lung Disease
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K24 HL123342
Start Year: 2014
End Year: 2019
Title: Longitudinal Evaluation of HIV-Associated Lung Disease Phenotypes
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125049
Start Year: 2014
End Year: 2018
Title: Translational Evaluation of Aging, Inflammation, and HIV in Lung Dysfunction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL120398
Start Year: 2013
End Year: 2018
Title: Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R21 HL114231
Start Year: 2012
End Year: 2015
Title: Statins for Pulmonary and Cardiac Complications of Chronic HIV (the SPARC Trial)
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R34 HL117344
Start Year: 2012
End Year: 2015
Title: Mechanism of Asthma in HIV Infected Individuals
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035041
Start Year: 2012
End Year: 2013
Title: Epidemiology and Significance of BNP in Large HIV-Infected Cohort
Role: Principal Investigator
Funding Agency: Roche Diagnostics
Start Year: 2010
End Year: 2014
Title: Epidemiology and Significance of BNP in a Large HIV-Infected Cohort
Role: Principal Investigator
Funding Agency: Gilead Sciences, Inc
Grant Number: DRUG
Start Year: 2010
End Year: 2014
Title: Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL098962
Start Year: 2009
End Year: 2016
Title: Prevalence & Pathogenesis Disease in a Large Multicenter HIV Cohort
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL90339
Start Year: 2007
End Year: 2014
Title: University of Pittsburgh Multicenter AIDS Cohort Study (MACS)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI035043
Start Year: 2016
End Year: 2017
Title: Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL128954
Start Year: 2015
End Year: 2020
Title: Anti-Influenza Hyperimmune Intravenous Immunoglobin Clinical Outcome Study
Role: Co-Investigator
Funding Agency: Institute for Clinical Research/National Institute of Allergy & Infectious Diseases
Start Year: 2015
End Year: 2017
Title: Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R56 HL128134
Start Year: 2015
End Year: 2016
Title: University of Pittsburgh Multicenter AIDS Cohort Study (MACS)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035041
Start Year: 2014
End Year: 2015
Title: Sarcoidosis and A1AT Genomics and Informatics Center-Administrative Supplement
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL112707
Start Year: 2014
End Year: 2015
Title: Benefits and Harms of Lung Cancer Screening in HIV Infection
Role: Co-Investigator
Funding Agency: University of Washington/National Cancer Institute
Grant Number: R01 CA173754
Start Year: 2013
End Year: 2018
Title: Pittsburgh Lung Conference 2013: Acute and Chronic Lung Infections: Novel Pathogens, Diagnostics, and Therapeutics
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R13 HL121917
Start Year: 2013
End Year: 2014
Title: Aging in HIV Associated Lung Dysfunction
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035041
Start Year: 2012
End Year: 2013
Title: Vascular Subphenotypes of Lung Disease - Core C
Role: Core Director
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016
Title: Vascular Subphenotypes of Lung Disease (Project 3)
Role: Project Leader
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Notable Achievements
Pittsburgh Best Doctors, 2012-2016
American Society for Clinical Investigation, 2012
University of Pittsburgh Critical Care Medicine Distinguished Alumni Award, 2014
Outstanding Mentor Award, PACCM, 2014
American Thoracic Society, Microbiology, Tuberculosis, and Pulmonary Infections Assembly, Mid-Level Peer Recognition Award, 2015