SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

[Return To Index page]
photo Frederico G. S. Toledo, MD

Associate Professor of Medicine

Director of Clinical Research, Center for Metabolic and Mitochondrial Medicine

Email: toledofs@upmc.edu

Phone: 412-692-2848

Contact
Office: NW810 Montefiore Hospital
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2848
Fax: 412-586-9726
E-mail: toledofs@upmc.edu
Administrative Assistant:
Chelsea Dempsey
Address: W1026 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: cad183@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
MD, Federal University of Rio de Janeiro, Brazil, 1996
Training
Postdoctoral Fellowship in Physiology, Mayo Clinic, MN, 1998
Residency, Internal Medicine, University of Miami, 2002
Fellowship, Endocrinology, University of Pittsburgh Medical Center, 2004
Research Interest
Pathophysiology of insulin resistance, diabetes and obesity
Pharmacological treatments for diabetes
Mitochondrial biology in insulin resistance of skeletal muscle
Muscle bioenergetics and effects of exercise on metabolism

Dr. Toledo's research focuses on the pathophysiology and treatment of insulin resistance and diabetes in humans. Dr. Toledo's clinical-translational lab employs state-of-the-art methods to measure metabolism in vivo in humans, such as clamps, IVGTTs, stable-isotope tracers, indirect calorimetry, controlled exercise testing, and tissue biopsies. His research program has been investigating the interplay between mitochondria, fuel metabolism, and insulin resistance in the context of diabetes and aging. Dr. Toledo pioneered studies that demonstrated for the first time the mitochondrial responses to lifestyle modifications in obesity and type 2 diabetes. Dr. Toledo's research also focuses on novel treatments for diabetes. He led an NIH-funded clinical study that demonstrated substantial beneficial effects of hydroxychloroquine on insulin resistance and beta cell function. His clinical research experience also includes agents such as rimonabant, vildagliptin, and AZD9668. He was a co-investigator in the TrialNet study consortium and participated in studies of type 1 diabetes prevention using immunomodulators.
Clinical Interest
Dr. Toledo's interests are general endocrinology, diabetes and obesity. He is interested in new models to enhance care. Dr. Toledo pioneered the development of video-consultation telemedicine care in the Division of Endocrinology. He led ground-breaking work demonstrating the feasibility, acceptability, and clinical efficacy of telemedicine in diabetes. He co-founded the diabetes telemedicine clinic, which currently provides outpatient adult diabetes care to medically-underserved areas in rural Pennsylvania.
Educational Interest
Dr. Toledo served as Associate Program Director for the Endocrinology Fellowship Program from 2005 through 2014. Since 2007, he has been a key faculty member of the Subspecialty Education Committee for the Internal Medicine Residency Program. He is also a key faculty member of the Oversight Committee of the T32 Training Program in Endocrinology.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Toledo, F. G., Watkins, S., Kelley, D. E. Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. The Journal of Clinical Endocrinology and Metabolism. 2006; 91: 3224-3227.
Toledo, F. G., Menishokva, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., Kelley, D. E. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes. 2007; 56: 2142-2147.
Toledo, F. G., Menshikova, E. V., Azuma, K., Radikova, Z., Kelley, C. A., Ritov, V. B., Kelley, D. E. Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes. 2008; 57: 987-994.
Chomentowski, P., Coen, P. M., Radikova, Z., Goodpaster, B. H., Toledo, F. G. Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. The Journal of Clinical Endocrinology and Metabolism. 2011; 96: 494-503.
Toledo, F.G., Goodpaster, B.H. The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging. Molecular and Cellular Endocrinology. 2013; 379(1-2): 30-4.
Toledo, F.G., Ruppert, K., Huber, K.A., Siminerio, L.M. Efficacy of the Telemedicine for Reach, Education, Access, and Treatment (TREAT) model for diabetes care. Diabetes Care. 2014; 37(8): 179-80.
DeLany, J.P., Dube, J.J., Standley, R.A., Distefano, G., Goodpaster, B.H., Stefanovic-Racic, M., Coen, P.M., Toledo, F.G. Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity. Journal of Clinical Endocrinology and Metabolism. 2014; 99(11): 4307-14.
Toledo, F.G. Mitochondrial involvement in skeletal muscle insulin resistance. Diabetes. 2014; 63(1): 59-61.
Wasko, M.C., McClure, C.K., Kelsey, S.F., Huber, K., Orchard, T., Toledo, F.G. Antidiabetogenic effects of hydroxychloroquine on insulin sensitivity and beta cell function: a randomised trial. Diabetologia. 2015; 58(10): 2336-43.
Piva, S.R., Susko, A.M., Khoja, S.S., Josbeno, D.A., Fitzgerlad, G.K., Toledo, F.G. Links between osteoarthritis and diabetes: implications for management from a physical activity perspective. Clinical Geriatric Medicine. 2015; 31(1): 67-87.
Sponsored Research/Activities
Title: Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer in Humans
Role: Principal Investigator
Funding Agency: American Diabetes Association
Start Year: 2013
End Year: 2016
Title: Mechanisms of Action of Hydroxychloroquine in Reducing Risk of Type 2 Diabetes
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R21 DK082878
Start Year: 2010
End Year: 2015
Title: Evaluation of BodyMedia Sensewear as a Potential Glucose-Sensing Device
Role: Principal Investigator
Funding Agency: Body Media, Inc.
Start Year: 2008
End Year: 2013
Title: Insulation Modulation of fMRI Connectivity and Food Reward
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R03 DK108976
Start Year: 2017
End Year: 2020
Title: Nitrite Benefits to Mediate Fatigability in Older HFpEF Patients
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG051637
Start Year: 2016
End Year: 2017
Title: Decreased Fat Oxidation - Metabolic Inflexibility in African American Women
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R56 DK091462
Start Year: 2015
End Year: 2017
Title: Neutrophil Elastase Inhibition as Adjunctive Therapy to Improve Glucometabolic Variables in Obese, Insulin-Resistant Type 2 Diabetic Patients
Role: Co-Investigator
Funding Agency: Allegheny-Singer Research Institute/Astra Zeneca
Start Year: 2015
End Year: 2017
Title: LABS Sub-Study: Mechanisms of Durability of Type 2 Diabetes Remission
Role: Co-Investigator
Funding Agency: Oregon Health Sciences/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK103842
Start Year: 2014
End Year: 2019
Title: Multicenter Prospective Randomized Clinical Trial of Plicated Laparoscopic Adjustable Gastric Banding
Role: Co-Investigator
Funding Agency: Duke University
Start Year: 2014
End Year: 2015
Title: Pitt-Ohio State - Georgetown Clinical Trials Unit
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI069494
Start Year: 2014
End Year: 2014
Title: Exploratory Study of Different Doses of Endurance Exercise in People with Parkinson's Disease
Role: Co-Investigator
Funding Agency: University of Colorado/National Institute of Neurological Disorder & Stroke
Grant Number: R01 NS074343
Start Year: 2013
End Year: 2015
Title: The Dynamics of Health, Aging, and Body Composition (Health ABC) Research Study
Role: Co-Investigator
Funding Agency: University of California - San Francisco/National Institute of Health
Start Year: 2012
End Year: 2015
Title: Trihepatanoin Therapy for Long-Chain Fatty Acid Oxidation Disorders
Role: Co-Investigator
Funding Agency: Oregon Health Sciences/Food and Drug Administration
Grant Number: R01 FD003895
Start Year: 2011
End Year: 2015