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Department of Medicine

Department of Medicine

  Division of General Internal Medicine

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photo Kaleab Z. Abebe, PhD

Associate Professor of Medicine, Biostatistics, and Clinical and Translational Science

Director, Center for Clinical Trials and Data Coordination (CCDC)

Co-Director, Career Education and Enhancement for Health Care Research Diversity (CEED) Program

Statistician, Center for Research on Health Care Data Center

Email: kza3@pitt.edu

Phone: 412-246-6931

Contact
Office: Center for Research on Health Care
200 Meyran Avenue, Suite 300
Pittsburgh, PA 15213
 
Phone: 412-246-6931
Fax: 412-586-9672
E-mail: kza3@pitt.edu
Education and Training
Education
BA, Mathematics, Goshen College, 2003
MA, Statistics, University of Pittsburgh, 2006
PhD, Statistics, University of Pittsburgh, 2009
Research Interest
Dr. Abebe's collaborative research focuses on design, conduct, and analysis of multicenter, randomized, controlled trials (RCTs), namely in polycystic kidney disease (PKD). He is the Data Coordinating Center (DCC) principal investigator for the HALT-PKD Network, comprising two, 7-site RCTs evaluating the impact of hypertensive medications and blood pressure control on PKD. He leads the DCC for an early phase RCT assessing safety and tolerability of metformin in PKD.

Dr. Abebe also oversees statistical cores of several comparative-effectiveness studies for gestational diabetes, collaborative care, HIV, and adolescent medicine. In addition, he is the founding director of the Center for Clinical Trials & Data Coordination, created to standardize the design, conduct, and analysis of RCTs.
Educational Interest
Dr. Abebe is involved in education and mentoring within the University of Pittsburgh's Institute for Clinical Research Education (ICRE). He is a graduate faculty member in the School of Medicine, as well as core faculty in the ICRE. He is the director of the Clinical Trials Track for the MS in Clinical Research; he currently teaches the Clinical Trials courses, but has also taught many of the biostatistics courses in the ICRE. In addition, Dr. Abebe is the co-director of the Career Education and Enhancement for Health Care Research Diversity (CEED) Program, which provides fellows and junior faculty who are underrepresented in academic medicine and health sciences with a solid foundation for research via professional development, networking, and mentoring.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Spirito, A., Abebe, K.Z., Iyengar, S., Brent, D., Vitiello, B., Clarke, G., Wagner, K.D., Asarnow, J., Emslie, G., Keller, M. Sources of site differences in the efficacy of a multisite clinical trial: the Treatment of SSRI-Resistant Depression in Adolescents. Journal of consulting and clinical psychology. 2009; 77(3): 439-50.
Torres, V.E., Grantham, J.J., Chapman, A.B., Mrug, M., Bae, K.T., King, B.F. Jr., Wetzel, L.H., Martin, D., Lockhart, M.E., Bennett, W.M., Moxey-Mims, M., Abebe, K.Z., Lin, Y., Bost, J.E., Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney disease. Clinical journal of the American Society of Nephrology. 2011; 6(3): 640-7.
Perrone RD, Abebe KZ, Schrier RW, Chapman AB, Torres VE, Bost J, Kaya D, Miskulin DC, Steinman TI, Braun W, Winklhofer FT, Hogan MC, Rahbari-Oskoui F, Kelleher C, Masoumi A, Glockner J, Halin NJ, Martin D, Remer E, et al. Cardiac magnetic resonance assessment of left ventricular mass in autosomal dominant polycystic kidney disease. Clinical journal of the American Society of Nephrology. 2011; 6(10): 2508-15.
Torres VE, Chapman AB, Perrone RD, Bae KT, Abebe KZ, Bost JE, Miskulin DC, Steinman TI, Braun WE, Winklhofer FT, Hogan MC, Oskoui FR, Kelleher C, Masoumi A, Glockner J, Halin NJ, Martin DR, Remer E, Patel N, et al. Analysis of baseline parameters in the HALT polycystic kidney disease trials. Kidney international. 2012; 81(6): 577-85.
Miskulin, D.C., Abebe, K.Z., Chapman, A.B., Perrone, R.D., Steinman, T.I., Torres, V.E., Bae, K.T., Braun, W., Winklhofer, F.T., Hogan, M.C., Rahbari-Oskoui, F., Moore, C.G., Flessner, M.F., Schrier, R.W., HALT-PKD Study. Health-Related Quality of Life in Patients With Autosomal Dominant Polycystic Kidney Disease and CKD Stages 1-4: A Cross-sectional Study. American Journal of Kidney Diseases: The Official Journal of The National Kidney Foundation. 2013; 63(2): 214-26.
Torres VE, Abebe KZ, Chapman AB, Schrier RW, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Moore CG, Perrone RD, the HALT-PKD Trial Investigators. Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease. The New England Journal of Medicine. 2014; 371(24): 2267-76.
Schrier RW, Abebe KZ, Perrone RD, Torres VE, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Bae KT, Moore CG, Chapman AB, the HALT-PKD Trial Investigators. Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease. The New England Journal of Medicine. 2014; 371(24): 2255-66.
Scifres, C.M., Abebe, K.Z., Jones, K.A., Comer, D.M., Costacou, T., Freiberg, M.S., Simhan, H.N., Day, N.L., Davis, E.M. Gestational Diabetes Diagnostic Methods (GD2M) Pilot Randomized Trial. Maternal and Child Health Journal. 2014; 19(7): 1472-80.
Moore, C.G., Spillane, S., Simon, G., Maxwell, B., Rahbari-Oskoui, F.F., Braun, W.E., Chapman, A.B., Schrier, R.W., Torres, V.E., Perrone, R.D., Steinman, T.I., Brosnahan, G., Czarnecki, P.G., Harris, P.C., Miskulin, D.C., Flessner, M.F., Bae, K.T., Abebe, K.Z., Hogan, M.C. Closeout of the HALT-PKD trials. Contemporary Clinical Trials. 2015; 44: 48-55.
Sponsored Research/Activities
Title: Data Coordinating Center for the Halt-Polycystic Kidney Disease Trials
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK082230
Start Year: 2013
End Year: 2017
Title: A Cluster Randomized Trial of a Supportive Care Intervention (CONNECT) for Patients with Advanced Cancer
Role: Co-Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA197103
Start Year: 2016
End Year: 2021
Title: Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease
Role: Co-Investigator
Funding Agency: Department of Defense
Start Year: 2015
End Year: 2020
Title: College Health Center-Based Alcohol and Sexual Violence Intervention
Role: Co-Investigator
Funding Agency: National Institute on Alcohol Abuse & Alcoholism
Grant Number: R01 AA023260
Start Year: 2014
End Year: 2019
Title: Expanding National Capacity in PCOR Through Training (ENACT)
Role: Co-Investigator
Funding Agency: Agency for Healthcare Research and Quality
Grant Number: R25 HS023185
Start Year: 2014
End Year: 2019
Title: Comparison of Two Screening Strategies for Gestational Diabetes
Role: Co-Investigator
Funding Agency: National Institute of Child Health & Human Development
Grant Number: R01 HD079647
Start Year: 2014
End Year: 2019
Title: Dipyridamole as a Modulator of HIV-1 Inflammation by Adenosine Regulation
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI1110410
Start Year: 2014
End Year: 2018
Title: Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL114016
Start Year: 2013
End Year: 2018
Title: Online Treatments for Mood and Anxiety Disorders in Primary Care
Role: Co-Investigator
Funding Agency: National Institute of Mental Health
Grant Number: R01 MH093501
Start Year: 2012
End Year: 2016
Title: Phase I Assessment of a Non Nucleotide Reverse Transcriptase
Role: Co-Investigator
Funding Agency: Magee Womens Hospital/Bill & Melinda Gates Foundation
Start Year: 2012
End Year: 2014
Title: University of Pittsburgh Clinical and Translational Science Institute - Research Education Core
Role: Co-Director
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR000005
Start Year: 2011
End Year: 2016
Title: Engendering Healthy Masculinities to Prevent Sexual Violence
Role: Data Manager
Funding Agency: Center for Disease Control
Grant Number: U01 CE002528
Start Year: 2014
End Year: 2018
Title: A Cluster-Randomized Trial of a Middle School Gender Violence Prevention Program
Role: Data Manager
Funding Agency: Center for Disease Control
Grant Number: R01 CE002543
Start Year: 2014
End Year: 2017
Title: Tailoring Clinical Interventions for Adolescent Relationship Abuse
Role: Statistician
Funding Agency: National Institute of Child Health & Human Development
Grant Number: K24 HD075862
Start Year: 2014
End Year: 2019
Title: Immunomodulatin by Hormonal Contraceptives among Adolescents and Young Women
Role: Statistician
Funding Agency: National Institute of Child Health & Human Development
Grant Number: R01 HD072663
Start Year: 2012
End Year: 2017
Title: Combination HIV Antiretroviral Rectal Microbicide Program
Role: Statistician
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U19 AI082637
Start Year: 2012
End Year: 2015
Notable Achievements
Student of the Year, Pittsburgh Chapter, American Statistical Association, 2008
Member, Society for Clinical Trials, 2010-Present
Ad Hoc Reviewer for: Journal of the Society for Clinical Trials, Journal of Clinical Oncology, PLoS ONE, Pain Medicine, 2011-Present
Chancellor’s Affirmative Action Award (on behalf of the CEED program), University of Pittsburgh., 2014
Ad Hoc Reviewer for the Kidney, Nutrition, Obesity, and Diabetes (KNOD) Study Section, NIH Center for Scientific Review, 2014, 2015
Co-Chair, Program Committee, 2017 Society for Clinical Trials Annual Conference (Liverpool, England), 2016
Chair, Program Committee, 2018 Society for Clinical Trials Annual Conference (Portland, OR), 2016