Department of Medicine

Department of Medicine

  Division of Cardiology

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photo François Yu, PhD

Research Instructor of Medicine


Phone: 412-648-8954

Office: Scaife Hall, Room 966.1
200 Lothrop Street
Pittsburgh, PA 15213
Phone: 412-648-8954
Education and Training
BS, Ecole Polytechnique de Montréal, Canada, 2001
Ph.D., University of Montreal, Canada, 2009
Research Interest
My research interests are focused on the use of ultrasound and microbubbles for imaging and therapeutic medical applications. They include sonoreperfusion therapy to address microvascular obstruction, ultrasound targeted drug delivery using microbubbles and liposomes, high frequency contrast ultrasound imaging for plaque vasa-vasorum imaging and ultrasound tissue characterization using high frequency spectral domain analysis.
Educational Interest
BIOENG 2505 (Fall): Multi-modality biomedical imaging technologies: functional, molecular, and hybrid imaging techniques and their applications

This class introduces the concept, fundamental physics, image analysis of multi-modality imaging techniques and systems, and their applications in biomedicine in different scales, from organ to cellular and molecular level, for both anatomical and functional imaging. The course also briefly addresses the issues related to image-based diagnosis, intervention, and therapy. This course is intended for graduate students, seniors, and researchers in biomedical engineering and medicines, as well as medical professionals who would like to obtain a basic understanding and current applications of newly developing medical imaging technologies.
For my complete bibliography, Click Here.
Selected Publications:
Yu F, Chen X, Villanueva FS, Pacella J. Sonoreperfusion for microvascular obstruction using ultrasound and microbubbles: role of nitric oxide. Journal of the American College of Cardiology. 2016; 67(13S): 161.
Yu FTH, Chen X, Wang J, Qin B, Villanueva FS. Low intensity ultrasound mediated liposomal doxorubicin delivery using polymer microbubbles. Mol Pharmaceutics. 2016; 13(1): 55-64.
Yu FTH, Villanueva FS, Chen X. Radial modulation contrast imaging using a 20-MHz single element intravascular ultrasound catheter. IEEE Trans Ultrason Ferroelect Freq Control. 2014; 61: 779-91.
Yu FTH, Armstrong JK, Tripette J, Meiselman HJ, Cloutier G. A local increase in red blood cell aggregation can trigger deep vein thrombosis: Evidence based on quantitative cellular ultrasound imaging. J Thrombosis Haemostasis. 2011; 9: 481-488.
Yu FTH, Franceschini E, Chayer B, Armstrong JK, Meiselman HJ, Cloutier G. Ultrasonic parametric imaging of erythrocyte aggregation using the Structure Factor Size Estimator. Biorheology. 2009; 46: 343-363.
Yu FTH, Cloutier G. Experimental ultrasound characterization of red blood cell aggregation using the structure factor size estimator. J Acoust Soc Am. 2007; 122: 645-656.
Sponsored Research/Activities
Title: Targeted Drug Delivery Using Liposomes, Microbubbles and Ultrasound
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB019582
Start Year: 2016
End Year: 2017
Title: Microbubble-Mediated Ultrasonic Therapy for Coronary Microvascular Obstruction
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125777
Start Year: 2015
End Year: 2020
Title: Hemostasis and Vascular Biology Research Institute - (Pacella)
Role: Research Assistant
Funding Agency: Institute for Transfusion Medicine
Grant Number: RES
Start Year: 2008
End Year: 2028
Notable Achievements
FRQS Post-doctoral fellowship , Mentor Dr Villanueva, 2011-2014
NSERC Ph.D. scholarship, mentor Dr Cloutier, 2005-2008