Dr. Simon’s research focus is understanding right ventricular (RV) adaptation and eventual failure in heart failure and pulmonary hypertension (PH) as a translational scientist. Dr. Simon’s labs focus on 1) advanced analysis of clinical hemodynamics, 2) integration of imaging and hemodynamics to better assess right ventricular function, and 3) early phase clinical trials in pulmonary hypertension and heart failure. His recent projects include a phase II study of inhaled nitrite for pulmonary hypertension (ClinicalTrials.gov NCT01431313), assessment of right ventricular-pulmonary arterial coupling in pulmonary hypertension patients and its relation to outcomes, right ventricular strain analysis by echocardiographic speckle tracking to screen a variety of patients for right ventricular dysfunction, assessment of right ventricular myocardial biaxial biomechanics in a murine model of pressure overload, and phenotyping a nonhuman primate model of HIV-associated pulmonary hypertension. He is involved with multiple clinical trials in pulmonary hypertension and heart failure with several leadership roles including 1) PI for the clinical core of a translational program project grant in pulmonary vascular disease (PI: Gladwin), 2) overseeing the Advanced Heart Failure and Cardiac Transplantation section’s clinical research portfolio of over 30 protocols with 3 full time clinical research coordinators, 3) director of the Montefiore University Hospital Clinical & Translational Research Center, a core lab in the University of Pittsburgh’s Clinical Translational Science Institute, which currently supports over 120 clinical research protocols for investigators. Dr. Simon has received research support from NIH, AHA, the Clinical Translational Science Institute of the University of Pittsburgh, and The Pittsburgh Foundation.