Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles
[Return To Index page]
photo John Pacella, MS,MD

Cardiology

Professor of Medicine

Email: pacellajj@upmc.edu

Phone: 412-647-5840
Contact
Office: Heart and Vascular Institute, UPMC Presbyterian
200 Lothrop Street, Suite A-350
Pittsburgh, PA 15213
 
Phone: 412-647-5840
Fax: 412-647-8117
E-mail: pacellajj@upmc.edu
Administrative Assistant:
Kimberly Ryan
Email: ryanks@upmc.edu
Education and Training
Education
MD, University of Pittsburgh, 1998
MS, Lehigh University, 1992
BS, Carnegie Mellon, 1990
Training
Internal Medicine, University of Pittsburgh, 2000
Cardiovascular Diseases, University of Pittsburgh, 2004
Interventional Cardiology, University of Pittsburgh, 2006
Research Interest
Developing therapy to optimize microvascular perfusion. NIH R01 funding to develop technique of sonorepefusion, which is the application of ultrasound to intravascular microbubbles to relieve microvascular obstruction and restore myocardial perfusion in the setting of percutaneous coronary intervention of acute myocardial infarction.
Clinical Interest
Interventional cardiology. General cardiology. Expertise in general cardiovascular medicine, non invasive cardiology, including echocardiography and nuclear cardiology. Additional expertise in cardiac catheterization and techniques in interventional cardiology therapies.
Educational Interest
Providing research mentoring for fellows, residents, graduate students and undergraduate students. Providing procedural education to fellows in cardiac catheterization techniques. Community outreach education.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Pacella JJ, Kameneva MV, Brands J, Lipowsky HH, VInk H, Lavery LL, Villanueva FS. Modulation of pre-capillary arteriolar pressure with drag reducing polymers: a novel method for enhancing microvascular perfusion. Microcirculation. 2012; 19: 580-585.
Leeman JE, Kim JS, Yu F, Chen X, Kim K, Wang J, Chen X, Villanueva FS, Pacella JJ. Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis. Ultrasound Med Biol. 2012; 38(2): 1589-98.
Kim JS, Leeman JE, Kagemann L, Yu FT, Chen X, Pacella JJ, Schuman JS, Villanueva FS, Kim K. Volumetric quantification of in vitro sonothrombolysis with microbubbles using high resolution optical coherence tomography. J Biomed Opt. 2012; 17(6) Mar-Apr: 070502.
Brands J, Kliner D, Lipowsky HH, Kameneva MV, Villanueva FS, Pacella JJ. New insights into the microvascular mechanisms of drag reducing polymers: effect on the cell-free layer. PLoS One. 2013; 8(10): e77252.
Chen X, Leeman JL, Wang J, Pacella JJ, Villanueva FS. New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging. Ultrasound Med Biol. 2014; 40(1): 258-262.
Webb TN, Ramratnam M, Evans RW, Orchard T, Pacella J, Erkan E. Atherosclerotic renal artery stenosis as a cause for hypertension in an adolescent patient. Pediatr Nephrol. 2014; 29(4): 1457-60.
Pacella JJ, Brands J, Schnatz FG, Chen X, Villanueva FS. Treatment of microvascular micro-embolization using microbubbles and long tone-burst-ultrasound: an in vivo study. Ultrasound Med Biol. 2015; 41(2): 456-564.
Chen X, Wang J, Pacella JJ, Villanueva FS. Dynamic behavior of microbubbles during long ultrasound tone-burst excitation: mechanistic insights into ultrasound-microbubble mediated therapeutics using high-speed imaging and cavitation detection. Ultrasound Med Biol. 2016; 42(2): 528-538.
Helfield B, Black JJ, Qin B, Pacella J, Chen X, Villanueva FS. Fluid viscosity affects the cavitation of lipid encapsulated microbubbles for therapeutic applications. Ultrasound Med Biol. 2016; 42(3): 782-794.
Black JJ, Yu FTH, Schnatz RG, Chen X, Villanueva FS, Pacella JJ. Effect of thrombus composition and viscosity on sonoreperfusion efficacy in a model of microvascular obstruction. Ultrasound Med Biol. 2016; epub in press_May 17, 2016.
Sponsored Research/Activities
Title: Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular Obstruction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL157497
Start Year: 2021
End Year: 2026
Title: Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstruction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R21 HL152312
Start Year: 2021
End Year: 2023
Title: Smart Electronic Stent for Surveillance of Coronary Artery Restenosis
Role: Principal Investigator
Funding Agency: National Institute of Health
Grant Number: R03 EB028928
Start Year: 2020
End Year: 2022
Title: Smart Electronic Stent for Surveillance of Coronary Artery Restenosis
Role: Principal Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R03 EB028928
Start Year: 2020
End Year: 2022
Title: Microbubble-Mediated Ultrasonic Therapy for Coronary Microvascular Obstruction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125777
Start Year: 2015
End Year: 2021
Title: Microbubble-Mediated Ultrasonic Therapy for Coronary Microvascular Obstruction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125777
Start Year: 2015
End Year: 2020
Title: Prevent Unnecessary Carotid Intervention and Stroke using Noninvasive Transcutaneous Ultrasound Thermal Strain Imaging (US-TSI)
Role: Co-Investigator
Funding Agency: National Institute of Health
Grant Number: R01 HL152023
Start Year: 2020
End Year: 2024
Title: Prevent Unnecessary Carotid Intervention and Stroke using Noninvasive Transcutaneous Ultrasound Thermal Strain Imaging (US-TSI)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL152023
Start Year: 2020
End Year: 2024
Title: Scar Detection and Treatment with Droplet Activation
Role: Co-Investigator
Funding Agency: University of Nebraska Med Center / National Heart, Lung, & Blood Institute
Grant Number: R01 HL146489
Start Year: 2020
End Year: 2022
Title: Scar Detection and Treatment with Droplet Activation
Role: Co-Investigator
Funding Agency: University of Nebraska Med Center / National Heart, Lung, & Blood Institute
Grant Number: R01 HL146489
Start Year: 2020
End Year: 2021
Title: Ultrasound-Stimulated Phase Change Contrast for Sonothrombolysis
Role: Co-Investigator
Funding Agency: Microvascular Therapeutics / National Heart, Lung, & Blood Institute
Grant Number: R43 HL152819
Start Year: 2020
End Year: 2021
Title: Imperceptible, Nanostructured Electronic Stent for Wireless Surveillance of Restenosis in Coronary Artery Disease
Role: Co-Investigator
Funding Agency: American Heart Association
Start Year: 2019
End Year: 2021
Title: Imperceptible, Nanostructured Electronic Stent for Wireless Surveillance of Restenosis in Coronary Artery Disease
Role: Co-Investigator
Funding Agency: American Heart Association
Grant Number: RES
Start Year: 2019
End Year: 2021
Title: Hemostasis and Vascular Biology Research Institute - (Pacella)
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Grant Number: RES
Start Year: 2008
End Year: 2028
Title: Hemostasis and Vascular Biology Research Institute - (Pacella)
Role: Co-Investigator
Funding Agency: Vitalant Research Institute
Grant Number: RES
Start Year: 2008
End Year: 2028

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
Copyright © 2022 Department of Medicine / University of Pittsburgh School of Medicine
Site maintained by the Department of Medicine domwebsite@PITT.EDU