Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Matthew Francis Muldoon, MD, MPH

Cardiology

Professor of Medicine

Email: mfm10@pitt.edu

Contact
 
E-mail: mfm10@pitt.edu
Research Interest
Dr. Muldoon conducts clinical research examining the interface of behavioral and biological risk factors for cardiovascular disease. Cardiovascular risk conveyed by hypertension, lipid disorders, insulin resistance and pre-clinical atherosclerosis are studied in relation to individual differences health behaviors (diet and exercise), cognition (attention, working memory, executive function, and impulsivity) and in mood (depression and anxiety). In addition, Dr. Muldoon has tested Interventions to treat or prevent hypertension, including prescribed pharmacotherapies, and nutritional supplements. His most recent work leverages e-health technologies to aid patients in self-management of their hypertension. He has lead or co-lead investigations using randomized and double-blind trial design, physiologic and ambulatory recordings, automated and bidirectional short-messaging systems, biomarker assessment, genomics and functional brain imaging. The majority of Dr. Muldoon’s research funding has come from competitive grants awarded by the National Institutes of Health (US Public Health Service).
Clinical Interest
Dr. Muldoon is a board-certified internist who has long directed the Hypertension Center at the University of Pittsburgh School of Medicine, while also serving as a primary care provider (PCP) at the Pittsburgh VA Healthcare System. He is the founding director of the Heart and Vascular Institute’s Hypertension Center which serves as a regional referral center for severe, secondary and otherwise problematic blood pressure disorders. Here, patients benefit from concurrent assessment and treatment by a certified clinical dietitian and clinical pharmacists as we work collaboratively with patients to optimize BP control through efficient use of both behavioral and pharmacology therapies. We seek discovery of individualized treatment for each patient based upon their medical history and current circumstances, both medical and psychosocial. At the Pittsburgh VA, Dr. Muldoon serves as a senior and widely-experienced primary care provider for a panel of our country’s veterans while also training internal medicine interns and residents in thorough, compassionate and cost-effective general outpatient care.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Ginty A, Muldoon MF, Kuan CHK, Kamarck TK, Jennings JR, Manuck SB, Gianaros PJ. Omega-3 supplementation and the neural correlates of negative affect and impulsivity: A double-blind, randomized, placebo-controlled trial in midlife adults. Psychosomatic Medicine. 2017; 79: 549-556.
Joseph NT, Muldoon MF, Manuck SB, Matthew KA, MacDonald L, Grosch J, Kamarck TK. The Role of Occupational Status in the Association between Job Strain and Ambulatory Blood Pressure during Working and Nonworking Days. Psychosomatic Medicine. 2016; 78: 940-949.
Miller KG, Wright AGC, Peterson LM, Andersen BA, Kirchbaum C, Marsland AL, Muldoon MF, Manuck SB. Trait Positive and Negative Emotionality Differentially Associate with Diurnal Cortisol Activity. Psychoneuroendocrinology. 2016; 68: 177-85.
Barger SD, Cribbett MR, Muldoon MF. Participant-Reported Health Status Predicts Cardiovascular and All-Cause Mortality Independent of Established and Nontraditional Biomarkers: Evidence From a Representative US Sample. Journal of the American Heart Association. 2016; 5: e003741.
Allen B, Muldoon MF, Gianaros PJ, Jennings JR. Higher blood pressure partially links greater adiposity to reduced brain white matter integrity. Hypertension. 2016; 29: 1029-37.
Muldoon MF, Manuck SM, Matthews KM. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. British Medical Journal. 1990; 301: 309-314.
Muldoon MF, Barger SD, Flory JD, Manuck SB. What are quality of life measurements measuring?. British Medical Journal. 1998; 316: 542-5.
Muldoon MF, Barger SD, Ryan CM, Flory JD, Lehoczky JP, Matthews KA, Manuck SB. Effects of lovastatin on cognitive function and psychological well-being. American Journal of Medicine. 2000; 108: 538-47.
Kamarck TW, Shiffman S, Sutton-Tyrrell K, Muldoon MF. Daily Psychological Demands Are Associated with Six-Year Progression of Carotid Artery Atherosclerosis: The Pittsburgh Healthy Heart Project. Psychosomatic Medicine. 2012; 74: 432-9.
McCaffery JM, Marsland AL, Strohacker K, Muldoon MF, Manuck SB. Factor structure underlying components of allostatic load. PLoS ONE. 2012; 7(10): e47246.
Sponsored Research/Activities
Title: Biobehavioral Studies of Cardiovascular Disease - Core B
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL040962
Start Year: 2018
End Year: 2023
Title: A Smartphone-Based Device for Cuff-Less and Calibration-Free Blood Pressure Monitoring
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL146470
Start Year: 2020
End Year: 2023
Title: Metabolic and Inflammatory Pathways of Midlife Neurocognitive Disparities
Role: Co-Investigator
Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases
Grant Number: R01 DK110041
Start Year: 2017
End Year: 2022
Title: Effect of Reducing Sedentary Behavior on Blood Pressure
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL134809
Start Year: 2017
End Year: 2022
Title: Experimental Study of Stress and DNA Damage in Humans: Mediators and Moderators
Role: Co-Investigator
Funding Agency: National Cancer Institute
Grant Number: R01 CA211371
Start Year: 2017
End Year: 2021
Title: Biobehavioral Mechanisms Linking Personality to Health in Midlife
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG056043
Start Year: 2016
End Year: 2021
Title: Biobehavioral Mechanisms Linking Personality to Health in Midlife
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG056043
Start Year: 2016
End Year: 2021
Notable Achievements
Elected member of the AOA Honor Medical Society, 1983
Masters Degree in Public Health, are of emphasis epidemiology, 1994
Fellow, American Heart Association, 2000
President, American Psychosomatic Society, 2008