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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Charles F. McTiernan, PhD

Research Associate Professor of Medicine

Email: mctiernanc@upmc.edu

Phone: 412-648-3016

Contact
Office: Cardiovascular Institute
200 Lothrop Street, Scaife 631A
Pittsburgh, PA 15213
 
Phone: 412-648-3016
Fax: 412-383-8857
E-mail: mctiernanc@upmc.edu
Education and Training
Education
PhD, Case Western Reserve University, 1982
B.A., College of the Holy Cross, 1975
Training
Postdoctoral training, Case Western Reserve University, 1987
Research Interest
My laboratory studies the molecular basis of cardiac remodeling in heart failure, for which employ a variety of cardiac function, cellular, molecular biology, and microscopic techniques. Our publications have appeared in Circulation Research, Circulation, Journal of the American College of Cardiology, Cardiovascular Research, and PNAS, among others. To date my research has covered 4 areas;

1) Proinflammatory cytokines in heart failure We demonstrated that transgenic overexpression of TNF generated a heart failure phenotype resembling that observed in human heart failure. Additional studies examined TNF effects on fibrosis and calcium handling.

2) TIMPs and MMPs in cardiac remodeling We reported that a) altered expression of TIMPs and MMPs occurs in failing human hearts, b) is responsive to mechanical unloading by ventricular assist devices, c) MMP-inhibition limits cardiac remodeling in a murine heart failure model, and d) the profile of TIMP and MMP expression varies with heart failure progression.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Zhu X, McTiernan CF, Rajagopalan N, Shah H, Fischer D, Toyoda Y, Letts D, Bortinger J, Gibson G, Xiang W, McCurry K, Mathier M, Glorioso JC, London BL. Immunosuppression decreases inflammation and increases AAV6-hSERCA2a mediated SERCA2a expression. Human Gene Therapy. 2012; 23: 722-732.
McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH, Mehdi H, Gibson G, Trichel AM, Glorioso JC, Feldman AM, McCurry KR, London B. Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Therapy. 2007; 14(23): 1613-22.
Ramani R, Vela D, Segura A, McNamara D, Lemster B, Samarendra V, Kormos R, Toyoda Y, Bermudez C, Frazier OH, Moravec CS, Gorcsan J, Taegtmeyer H, McTiernan, CF. A MicroRNA Signature Associated with Recovery from Assist Device Support in Two Groups of Patients with Severe Heart Failure. Journal of the American College of Cardiology. 2011; 58: 2270-8.
McGaffin, KR, Moravec CA, McTiernan CF. Leptin signaling in the failing and mechanically unloaded human heart. Circulation: Heart Failure. 2009; 2: 676-83.
Mori S, Gibson G, McTiernan CF. Differential expression of MMPs and TIMPs in moderate and severe heart failure in a transgenic model. Journal of Cardiac Failure. 2006; 12: 314-25.
Janczewski AM, Zahid M, Lemster BH, Frye CS, Gibson G, Higuchi Y, Kranias EG, Feldman AM, McTiernan CF. Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovascular Research. 2004; 62: 468-80.
Li YY, Feldman AM, Sun Y, McTiernan CF. Differential expression of tissues inhibitors of metalloproteinases in failing human heart. Circulation. 1998; 98: 1728-34.
Kubota T, McTiernan CF, Frye CS, Slawson SE, Koretsky AP, Demetris AJ, Feldman AM. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circulation Research. 1997; 81: 627-35.
McTiernan CF, Ramani R, Burkhead B, McNamara D. The Methionine 196 Arginine Polymorphism of the TNF Receptor 2 Gene (TNFRSF1B) is Not Associated with Worse Outcomes in Heart Failure. Cytokine. 2012; 60: 838-42.
McTiernan CF, Lemster BH, Frye CS, Johns DJ, Feldman AM. Characterization of proximal transcription regulatory elements in the rat phospholamban promoter. Journal of Molecular and Cellular Cardiology. 1999; 31: 2137-53.
Sponsored Research/Activities
Title: Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125886
Start Year: 2014
End Year: 2018
Title: Ultrasound-Activated Microbubbles for Targeted siRNA Delivery to Tumor
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R01 EB016516
Start Year: 2012
End Year: 2016
Title: In Vivo Electrophysiology Imaging
Role: Co-Investigator
Funding Agency: University of Iowa/National Heart, Lung, & Blood Institute
Grant Number: DP1 HL117648
Start Year: 2012
End Year: 2013
Title: Genetic Risk Factors of Myocyte Contractility in Human Heart Failure
Role: Co-Investigator
Funding Agency: University of Minnesota/National Heart, Lung, & Blood Institute
Grant Number: R21 HL104596
Start Year: 2011
End Year: 2013
Title: University of Pittsburgh Clinical and Translational Science Institute
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR000005
Start Year: 2006
End Year: 2016