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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Dennis M McNamara, MD

Professor of Medicine

Director, Center for Heart Failure Research

Co-Director, Peripartum Cardiomyopathy Network

Email: mcnamaradm@upmc.edu

Phone: 412-648-6598

Contact
Office: UPMC Heart and Vascular Institute
200 Lothrop Street, Scaife Hall, Room S-566
Pittsburgh, PA 15213
 
Phone: 412-648-6598
Fax: 412-648-6101
E-mail: mcnamaradm@upmc.edu
Administrative Assistant:
Shelly Ossman
Email: ossmanmr@upmc.edu
Phone: 412-648-6598
Education and Training
Education
BS, Yale University, 1983
MD, Harvard Medical School, 1987
Training
Internal Medicine, Massachusetts General Hospital, 1988
Cardiology, Massachusetts General Hospital, 1993
Research Interest
Research interest focus on the impact of genomics on clinical outcomes, and the use of genetic variation for targeting therapeutic interventions. In addition the use of genetic background and biomarker assessment for predicting myocardial recovery in recent onset non-ischemic cardiomyopathy.
Clinical Interest
Actively involved in clinical care of subjects with heart failure. In particular our clinical practice has a particular interest in recent onset non-ischemic cardiomyopathy including women with peripartum cardiomyopathy. In addition we care for subjects with advanced heart failure referred for possible cardiac transplantation or left ventricular assist device (LVAD) implantation. We also care for subjects with signifciant pulmonary hypertension.
Educational Interest
We are actively involved in the training of cardiology fellows in advanced heart failure and the management of pulmonary hypertension. Training encompasses the management of subjects on left ventricular assist devices (LVADs) as well as those post cardiac transplantation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ,, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK,, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U,, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J,, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd,, McNamara DM, Seidman CE, Seidman JG, Arany Z and; IMAC-2 and IPAC Investigators. Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med. 2016; 374(3): 233-41.
Damp J, Givertz MM, Semigran M,, Alharethi R, Ewald G, Felker GM,, Bozkurt B, Boehmer J, Haythe J,, Skopicki H, Hanley-Yanez K, Pisarcik J,, Halder I, Gorcsan J 3rd, Rana S, Arany Z,, Fett JD, McNamara DM and IPAC Investigators. Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study. JACC Heart Fail. 2016; 4(5): 380-8.
Sheppard R, Hsich E, Damp J, Elkayam U, Kealey A, Ramani G, Zucker M, Alexis JD, Horne BD, Hanley-Yanez K, Pisarcik J, Halder I, Fett JD, McNamara DM, IPAC Investigators. GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study. Circ Heart Fail. 2016; 9(3): e002683.
McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, Modi K, Alexis JD, Ramani GV, Semigran MJ, Haythe J, Markham DW, Marek J, Gorcsan J 3rd, Wu WC, Lin Y, Halder I, Pisarcik J, Cooper LT, Fett JD, IPAC Investigators. Clinical Outcomes for Peripartum Cardiomyopathy in North America: Results of the IPAC Study (Investigations of Pregnancy-Associated Cardiomyopathy). J Am Coll Cardiol. 2015; 66(8): 905-14.
McNamara DM, Taylor AL, Tam SW, Worcel M, Yancy CW, Hanley-Yanez K, Cohn JN, Feldman AM. G-protein beta-3 subunit genotype predicts enhanced benefit of fixed-dose isosorbide dinitrate and hydralazine: results of A-HeFT. JACC Heart Fail. 2014; 2(6): 551-7.
McNamara DM, Starling RC, Cooper LT, Boehmer JP, Mather PJ, Janosko KM, Gorcsan J 3rd, Kip KE, Dec GW, IMAC Investigators. Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J Am Coll Cardiol. 2011; 58(11): 1112-8.
McNamara DM, Tam SW, Sabolinski ML, Tobelmann P, Janosko K, Venkitachalam L, Ofili E, Yancy C, Feldman AM, Ghali JK, Taylor AL, Cohn JN, Worcel M. Endothelial nitric oxide synthase (NOS3) polymorphisms in African Americans with heart failure: results from the A-HeFT trial. J Card Fail. 2009; 15(3): 191-8.
Sheppard R, Bedi M, Kubota T, Semigran MJ, Dec W, Holubkov R, Feldman AM, Rosenblum WD, McTiernan CF, McNamara DM, IMAC Investigators. Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy. J Am Coll Cardiol. 2005; 46(6): 1036-42.
Cooper LT, Virmani R, Chapman NM, Frustaci A, Rodeheffer RJ, Cunningham MW, McNamara DM. National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy. Mayo Clin Proc. 2006; 81(2): 199-204.
Feldman AM, McNamara DM. Myocarditis. New Engl J Med. 2000; 343(19): 1388-98.
Sponsored Research/Activities
Title: Genomic Analysis of Enhanced Response to Heart Failure Therapy in African Americans
Role: Principal Investigator
Funding Agency: National Institute on Minority Health and Health Disparities
Grant Number: R01 MD009118
Start Year: 2014
End Year: 2019
Title: Racial Genomic Differences and Heart Failure Outcomes
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K24 HL069912
Start Year: 2009
End Year: 2014
Title: Immune Activation and Myocardial Recovery in Peripartum Cardiomyopathy
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: RC1 HL102429
Start Year: 2009
End Year: 2013
Title: Cyb5R3 and cGMP Signaling
Role: Co-Investigator
Funding Agency: Bayer Corporation
Grant Number: RES
Start Year: 2017
End Year: 2019
Title: Data and Clinical Coordinating Center (DCC) for the Randomized Evaluation of VADInterVEntion Before Inotropic Therapy (REVIVE-IT)
Role: Co-Investigator
Funding Agency: University of Michigan/National Institute of Health
Start Year: 2011
End Year: 2016