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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Kang Kim, PhD

Associate Professor of Medicine

Associate Professor, Department of Biomedical Engineering

Email: kangkim@upmc.edu

Contact
Office: UPMC Cardiovascular Institute
623 Scaife Hall, 200 Lothrop Street
Pittsburgh, PA 15213
 
E-mail: kangkim@upmc.edu
Administrative Assistant:
April Youschak
Email: youschakal@upmc.edu
Education and Training
Education
PhD, Pennsylvania State University
Training
Postdoctoral Fellow, University of Michigan
Research Interest
Our laboratory seeks to develop and translate state of the art noninvasive imaging technologies to (1) improve disease diagnosis, (2) guide therapeutic strategies and (3) evaluate therapeutic efficacy. Our research emphasis is on development and application of hybrid ultrasound imaging systems that are based on a fundamental understanding of how sound and light interact with soft tissue, and are capable of capable of assessing their mechanical, compositional, and biological characteristics. Three independent, but related, imaging technologies are under active investigation:

(1) Ultrasound elasticity imaging (UEI)/shear wave elasticity imaging (SWEI) non-invasively assesses the global and regional mechanical properties of the soft tissues and organs.

(2) Ultrasound Thermal Strain Imaging (TSI) strongly contrasts lipids from the surrounding non-lipid tissues.

(3) Photoacoustic Imaging (PAI)/Photoacoustic molecular imaging (PMI) combines laser and ultrasound technologies to detect optical contrast in tissues and identify specific biomarkers that may enable early detection of disease and its treatment evaluation.

These three imaging modalities may also be combined to provide a more complete characterization of disease. Noninvasive imaging technologies such as these will also be pivotal for preclinical animal studies, significantly reducing animal numbers, variation between subjects, and shortening the study period. In my research laboratory, we envision a noninvasive hybrid imaging system, integrating all these technologies into a single bed-side ultrasound platform. This will provide a powerful, safe, and cost-effective adjunct to clinical practice by identifying patients at early stages of disease and improving treatment strategies.
Educational Interest
Class teaching:
BIOENG 2505: Multi-modality biomedical imaging technologies: functional,
molecular, and hybrid imaging techniques and their applications (Course Developer, Course Director, and Instructor)
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kim, K, Agarwal A, Huang SW, Denny MF, Kaplan MJ, Ashkenazi S, O'Donnell M, Kotov NA. Photoacoustic imaging of early inflammatory response using gold nanorods. Appl Phys Lett. 2007; 90(223901): 1-3.
Ha S, Carson A, Kim K. Ferritin as a novel reporter gene for photoacoustic molecular imaging. Cytometry Part A. 2012; 81(10): 910-915.
Kim K, Johnson LA, Jia C, Joyce JC, Higgins PDR, Rangwalla S, Rubin JM. Non-invasive ultrasound elasticity imaging (UEI) on Crohn’s disease: Animal model. Ultrasound Med Biol. 2008; 34(6): 902-912.
Stidham RW, Xu J, Johnson LA, Kim K, Moons DS, McKenna BJ, Rubin JM, Higgins PDR. Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease. Gastroenterology. 2011; 141(3): 819-82.
Kim K, Jeong CG, Hollister SJ. Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imaging. Acta Biomater. 2008; 4(4): 783-790.
Yu J, Takanari K, Hong Y, Lee KW, Amoroso NJ, Wang Y, Wagner WR, Kim K. Non-invasive characterization of polyurethane-based tissue constructs in a rat abdominal repair model using high frequency ultrasound elasticity imaging. BIomaterials. 2013; 34(11): 2701-2709.
Park DW, Ye SH, Jiang HB, Dutta D, Nonaka K, Wagner WR, Kim K. In vivo monitoring of structural and mechanical changes of tissue scaffolds by multi-modality imaging. Biomaterials. 2014; 35(27): 7851-7859.
Kim K, Huang SW, Hall TL, Witte RS, Chenevert TL, O'Donnell M. Arterial vulnerable plaque characterization using ultrasound induced thermal strain imaging (TSI). IEEE Trans Biomed Eng. 2008; 55(1): 171-180.
Mahmoud A, Dutta D, Lavery L, Stephen DN, Villanueva FS, Kim K. Noninvasive detection of lipids in atherosclerotic plaque using ultrasound thermal strain imaging: in vivo animal study. Journal of American College of Cardiology. 2013; 62(19): 1804-1809.
Kim K, William RW. Non-invasive and non-destructive characterization of tissue engineered constructs using ultrasound imaging technologies: a review. Ann Biomed Eng. 2016; 44(3): 621-635.
Sponsored Research/Activities
Title: Noninvasive Fat Quantification of Liver Using Ultrasound Thermal Strain Imaging
Role: Principal Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB016907
Start Year: 2014
End Year: 2016
Title: A Novel Shear Wave Approach to Non-Invasively Assess Mechanical Properties of Liver for Early Diagnosis and 3D Organ Modeling
Role: Principal Investigator
Funding Agency: Samsung Electronics
Start Year: 2012
End Year: 2015
Title: Noninvasive Monitoring of Tissue Engineered Constructs by US Elasticity Imaging
Role: Principal Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB013353
Start Year: 2011
End Year: 2013
Title: Ultrasound-induced Thermal Strain Imaging for arterial Plaque Characterization
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098230
Start Year: 2010
End Year: 2016
Title: Development of a Novel Multi-Modal In Vivo Imaging System for Animal-to-Human Use
Role: Principal Investigator
Funding Agency: Sogang University
Start Year: 2010
End Year: 2015
Title: CPS: Synergy: Collaborative Research: Closed-loop Hybrid Exoskeleton Utilizing Wearable Ultrasound Imaging Sensors for Measuring Fatigue
Role: Co-Principal Investigator
Funding Agency: National Science Foundation
Grant Number: RES
Start Year: 2017
End Year: 2020
Title: NRI: Maneuverable Feedback-Controlled Micro Swimming Drone for Biomedical Applications
Role: Co-Principal Investigator
Funding Agency: National Science Foundation
Grant Number: RES
Start Year: 2016
End Year: 2019
Title: Targeted Drug Delivery Using Liposomes, Microbubbles and Ultrasound
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB019582
Start Year: 2016
End Year: 2017
Title: Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging
Role: Co-Investigator
Funding Agency: University of California/Irvine/National Heart, Lung, & Blood Institute
Grant Number: R01 HL125084
Start Year: 2014
End Year: 2018
Title: Biometric Coacervate Delivery of Muscle Stem Cell to Improve Cardiac Repair
Role: Co-Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB016774
Start Year: 2014
End Year: 2016
Title: Carbon Nanotube Biodegradation by Neutrophil Myeloperoxidase
Role: Co-Investigator
Funding Agency: Center for Disease Control
Grant Number: R01 OH008282
Start Year: 2010
End Year: 2015