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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Partha Dutta, DVM, PhD

Assistant Professor of Medicine

Email: duttap@upmc.edu

Phone: 412-383-6030

Contact
Office: 1720.1 BST
200 Lothrop St
Pittsburgh, PA 15213
 
Phone: 412-383-6030
Fax: 412-624-9160
E-mail: duttap@upmc.edu
Administrative Assistant:
Diane Margaria
Email: margariad@upmc.edu
Phone: 412-383-6030
Education and Training
Education
DVM, West Bengal University of Animal and Fishery Sciences, India, 2003
MS, Wichita State University, KS, 2006
PhD, University of Wisconsin-Madison, WI, 2010
Training
Postdoctoral Training, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 2013
Instructor, Harvard Medical School, 2015
Research Interest
Cardiovascular disease is the leading cause of death in developed countries. Inflammation aggravates outcome of cardiovascular disease including atherosclerosis and infarct healing after myocardial infarction (MI). During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons.
Another area of my research interest is fate and differentiation of hematopoietic stem and progenitor cells in cardiovascular disease. Hematopoietic stem cells get activated after acute or chronic inflammation and give rise to exaggerated myelopoiesis. However, most hematopoietic stem cells (HSC) are quiescent, and it is currently unknown whether they respond to ischemic organ injury. We identified a CCR2+ HSC subset, which has fourfold higher proliferative rate than CCR2- HSC, as the most upstream contributor to myelopoiesis after myocardial infarction. CCR2+ HSC display bias towards the myeloid lineage and dominate the migratory HSC population after myocardial infarction and in steady-state. These data shed new light on the regulation of emergency hematopoiesis after ischemic injury and identify novel therapeutic targets to modulate leukocyte output after myocardial infarction.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Dutta P, Sager H, Stengel K, Naxerova K, ..., Libby P, Hiebert S, Scadden D, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction activates CCR2+ hematopoietic stem cells. Cell Stem Cell. 2015; 16: 477-487.
Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, DaSilva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 in atherosclerosis. Journal of Experimental Medicine. 2015; 212: 497-512.
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Targeting interleukin-1beta reduces leukocyte production after acute myocardial infarction. Circulation. 2015; 132(20): 1880-1890.
Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, THompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, ..., Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature. 2012; 487: 325-329.
Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nature Medicine. 2014; 20: 754-758.
Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, ..., Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature Biotechnology. 2011; 29: 1005-1010.
Dutta P, Dart M, Roenneburg DA, Torrealba JR, Burlingham WJ. Pretransplant immune-regulation predicts allograft tolerance. American Journal of Transplantation. 2011; 11: 1296-1301.
Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, Burlingham WJ. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood. 2009; 114: 3578-3587.
Sponsored Research/Activities
Title: Effect of Diabetes on Myelopoiesis and Atherosclerosis
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R00 HL121076
Start Year: 2015
End Year: 2018
Notable Achievements
Featured Scientist in Fall 2014 TPEN Newsletter, 2014
Keystone Symposia Future of Science Fund Scholarship, 2014
American Heart Association Fellowship, 2012
MGH Scientific Advisory Committee 2012 Poster Distinction Award, 2012
American Society of Transplantation Basic Science Fellowship, 2012
University of Wisconsin-Madison Vilas Travel Grant, 2009
Ray Owen Registration Award at Midwinter Conference of Immunologists, 2008
National Merit Scholarship, 1996