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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Stephen Y. Chan, MD, PhD, FAHA

Associate Professor of Medicine

Director, Center for Pulmonary Vascular Biology and Disease

Associate Program Director, Fellowship Research, Cardiovascular Fellowship Training Program

Email: chansy@upmc.edu

Phone: 412-383-6030

Contact
Office: 1704.2 BST
200 Lothrop St
Pittsburgh, PA 15216
 
Phone: 412-383-6030
Fax:
E-mail: chansy@upmc.edu
Administrative Assistant:
Diane Margaria
Email: margariad@upmc.edu
Phone: 412-383-6030
Education and Training
Education
PhD, University of California, San Francisco, CA, 2001
MD, University of California, San Francisco, CA, 2003
Training
Residency, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 2005
Clinical and Research Fellowship in Cardiology, Massachusetts General Hospital, Boston, MA, 2009
Research Fellow in Medicine, Harvard Medical School, Boston, MA, 2009
Research Interest
I lead a basic science and translational research group studying the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH) – an example of an enigmatic disease where reductionistic studies have primarily focused on end-stage molecular effectors. To capitalize on the emerging discipline of "network medicine," our research utilizes a combination of network-based bioinformatics with unique experimental reagents derived from genetically altered rodent and human subjects to accelerate systems-wide discovery in PH. Our published findings were among the first to identify the systems-level functions of microRNAs (miRNAs), which are small, non-coding RNAs that negatively regulate gene expression, as a root cause of PH. Our lab developed novel in silico approaches to analyze gene network architecture coupled with in vivo experimentation. The results now offer methods to identify persons at-risk for PH and develop therapeutic RNA targets. This work is the cornerstone of our evolving applications of network theory to the discovery of RNA-based origins of human diseases, in general.
Clinical Interest
I serve as Director for the Center for Pulmonary Vascular Biology and Medicine, a multidisciplinary clinical and research center devoted to the care of patients afflicted with pulmonary vascular diseases. I have an outpatient clinic where I specialize in the care of patients with pulmonary hypertension. I also serve as an attending physician on the inpatient general cardiology service.
Educational Interest
I am invested in educating both scientists and physicians in cardiovascular and pulmonary vascular medicine. I have served as the primary research mentor for 11 trainees over the past 4 years, including 6 postdoctoral fellows, 1 doctoral student, and 4 undergraduate students. Of my post-doctoral trainees, two post-doctoral fellows have since started independent academic laboratories as PI’s, two have transitioned to principal scientist positions in industry, and two are current fellows in my lab. The doctoral student is currently a cardiology fellow at Stanford pursuing an academic research career. Of the undergraduate students, one has matriculated to the UPenn MSTP and another has matriculated in a Ph.D. program in biology at the University of North Carolina. I serve as Associate Fellowship Director in Cardiology where I direct the research program for our fellows. I also enjoy teaching both graduate and post-graduate trainees on the inpatient cardiology service and in didactic settings.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, ..., CHAN SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. The Journal of Clinical Investigation. 2014; 124: 3514-3528.
CHAN SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metabolism. 2009; 10(4): 273-284.
Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, CHAN SY. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. Journal of Physiology. 2011; 589: 3983-3994.
Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, Barabasi AL, Loscalzo J, CHAN SY. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012; 125: 1520-1532.
Snow JW, Hale A, Isaacs SK, Baggish AL, CHAN SY. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biology. 2013; 10: 1107-1116.
Baggish AL, Park J, Min PK, Isaacs SK, Parker BA, Thompson PD, Troyanos C, D'Hemecourt P, Dyer S, Thiel M, Hale A, CHAN SY. Rapid up-regulation and clearance of distinct circulating microRNAs after prolonged aerobic exercise. Journal of Applied Physiology. 2014; 116: 522-531.
Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, CHAN SY. An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells. Biochim Biophys Acta Molecular Cell Research. 2014; 1843: 2528-2542.
Bertero T, Cottrill K, Krauszman A, Lu Y, Annis S, Hale A, Bhat B, Waxman AB, Chau BN, Kuebler WM, CHAN SY. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. Journal of Biological Chemistry. 2015; 290: 2069-2085.
White K, Lu Y, Annis S, Hale AE, Chau N, Dahlman JE, Hemann C, Opotowsky A, Vargas SO, I R, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, ..., CHAN SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Molecular Medicine. 2015; 7: 695-713.
Parikh V, Park J, Nikolic I, Channick R, Yu PB, DeMarco T, Hsue P, CHAN SY. Coordinated modulation of circulating miR-21 in HIV, HIV-associated pulmonary arterial hypertension, and HIV/HCV co-infection. Journal of Acquired Immune Deficiency Syndromes. 2015; 70(3): 236-241.
Sponsored Research/Activities
Title: Iron-Sulfur Deficiency as a Critical Pathogenic Cause of Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL122596
Start Year: 2015
End Year: 2020
Title: Defining the Complex Biology of the miR-130/131 Family in Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL124021
Start Year: 2015
End Year: 2019
Title: Interrogating an Argonaute 2 Switch to Regulate Circulating miR-210 and to Coordinate Remote Ischemic Protection
Role: Principal Investigator
Funding Agency: American Heart Association-National
Start Year: 2015
End Year: 2017
Title: Exercise-Induced Concentric Left Ventricular Hypertrophy: Unrecognized Pathology
Role: Co-Investigator
Funding Agency: Massachusetts General Hospital/National Heart, Lung, & Blood Institute
Grant Number: R01 HL125869
Start Year: 2015
End Year: 2020
Title: Induction of Oncogenic MicroRNA by Rapamycin: Role in TSC Therapy
Role: Co-Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK102146
Start Year: 2015
End Year: 2020
Title: Role of microRNA in the Pathogenesis and Treatment of TSC
Role: Co-Investigator
Funding Agency: Brigham and Women's Hospital, Inc./Department of Defense
Start Year: 2015
End Year: 2018
Notable Achievements
Elected Member, American Society for Clinical Investigation, 2016
Chair's Prize for Research Excellence, Brigham and Women's Hospital, 2015
Prince Mansour Bin Bandar Al Saud Prize, Saudi Association for Pulmonary Hypertension, 2014
Cardiovascular Leadership Council Award, Brigham and Women's Hospital, 2013
Jeremiah Stamler Distinguished Young Investigator Research Award, Northwestern University, 2011
Susan & Katherine McArthur-Radovsky Award, Brigham and Women's Hospital, 2011