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Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Dennis Bruemmer, MD, PhD

Associate Professor of Medicine

Email: bruemmerd@upmc.edu

Phone: 412-383-6030

Contact
Office: 1744.2 BST
200 Lothrop St
Pittsburgh, PA 15213
 
Phone: 412-383-6030
Fax:
E-mail: bruemmerd@upmc.edu
Administrative Assistant:
Diane Margaria
Email: margariad@upmc.edu
Phone: 412-383-6030
Education and Training
Education
MD, University Hospital Eppendorf, Hamburg, Germany, 1998
Training
Residency, Internal Medicine/Cardiology, Humboldt University, Berlin, 2003
Research Fellowship, University of California, Los Angeles, CA, 2003
Clinical Fellowship, Endocrinology, Diabetes, Metabolism, University of Kentucky, 2009
Clinical Fellowship, Cardiovascular Medicine, University of Kentucky, 2016
Research Interest
Dr. Bruemmer’s research program is focused on basic investigation of mechanisms underlying tissue remodeling during atherosclerosis and neointima formation. Dr. Bruemmer’s laboratory is currently investigating the role of telomerase and telomere attrition in obesity, diabetes, and cardiovascular disease. Specifically, he is interested to determine the transcriptional mechanisms by which telomere biology impacts cell proliferation and inflammation in diabetes and cardiovascular disease.
Clinical Interest
Dr. Bruemmer currently practices General Cardiology. Having completed dual clinical training in the subspecialties of Endocrinology and Cardiology, he is primarily interested in Preventive Cardiology and Cardiovascular Risk Stratification and Modification. He is particularly interested in improving strategies for the management of diabetes in patients with Cardiovascular Diseases.
Educational Interest
Dr. Bruemmer's educational interest is primarily in the mentoring of clinical residents and fellows pursuing physician-scientists tracks in an academic environment. In addition, Dr. Bruemmer mentors Graduate Students and Postdoctoral Research Fellows in his laboratory to pursue independent academic research careers.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA. Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. Journal of Clinical Investigation. 2003; 112(9): 1318-1331.
Ogawa D, Nomiyama T, Nakamachi T, Heywood EB, Stone JF, Berger JP, Law RE, Bruemmer D. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circulation Research. 2006; 98(7): e50-9.
Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. Journal of Clinical Investigation. 2007; 117(10): 2877-88.
Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D. The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circulation Research. 2008; 103(10): 1155-63.
Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation. 2009; 119(4): 577-86.
Brown A, Reynolds LR, Bruemmer D. Intensive glycemic control and cardiovascular disease: an update. Nature Reviews Cardiology. 2010; 7(7): 369-375.
Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circulation Research. 2010; 107(4): 501-11.
Qing H, Liu Y, Zhao Y, Aono J, Jones KL, Heywood EB, Howatt D, Binkley CM, Daugherty A, Liang Y, Bruemmer D. Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis. Stem Cells. 2014; 32(9): 2419-29.
Aono J, Ruiz-Rodriguez E, Qing H, Findeisen HM, Jones KL, Heywood EB, Bruemmer D. Telomerase Inhibition by Everolimus Suppresses Smooth Muscle Cell Proliferation and Neointima Formation Through Epigenetic Gene Silencing. JACC: Basic to Translational Science. 2016; 1(1-2): 49-60.
Notable Achievements
Henry I Russek Award, American College of Cardiology, 2014
Novo Nordisk Scholarship Award, American Association of Clinical Endocrinology, 2009
Career Development Award, American Diabetes Association, 2008
National Scientist Development Award, American Heart Association, 2008
Irvine H. Page Young Investigator Research Award,, 2004
Young Scholar Award, American Society of Hypertension, 2004
ATVB Merit Award for Young Investigators, 2004
Young Investigator Award, The Endocrine Society, 2003