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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Xiuxia Zhou, PhD

Research Assistant Professor

Email: zhoux@upmc.edu

Phone: 412-864-2615

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-864-2615
Fax: 412-605-1999
E-mail: zhoux@upmc.edu
Education and Training
Education
BS, Biochemistry, Lanzhou University, 1986
MS, Biochemistry, Hebei Medical University, 1995
PhD, Biochemistry and Molecular Biology, Hebei Medical University, 2000
Research Interest
Dr. Zhou’s research work has been focused on the signaling pathways related to extracellular matrix turnover and the role and function of chemoattractant molecules in primary human lung fibroblasts. Specifically, her work involves:
1.Cellular responses to IL-13 and TGF-ß in fibroblasts during lung inflammation and repair in asthma. Dr. Zhou’s studies focus on the TGF-ß and IL-4Ra signaling pathways on extracellular matrix metabolism, airway inflammation and remodeling in primary human fibroblasts obtained from normal and asthmatic subjects.
2.Regional fibroblasts heterogeneity in asthma. Dr. Zhou has been interested in regulatory mechanisms that determine the differences between fibroblasts isolated from proximal and distal lung. Dr. Zhou has successfully transfected primary human lung fibroblasts with dominant negative constructs or siRNA, and would like to fully understand the mechanisms controlling their phenotypic differences using an epigenetic approach.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Watanabe, T, Fajt, ML, Trudeau, JB, Voraphani, N, Hu, H, Zhou, X, Holguin, F, Wenzel, SE. Brain-Derived Neurotrophic Factor Expression in Asthma. Association with Severity and Type 2 Inflammatory Processes. Am J Respir Cell Mol Biol. 2015; Dec;53(6): 844-52.
Zhou, X, Hu, H, Balzar, S, Trudeau, JB, Wenzel, SE. MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-ß1 and IL-13 in human airway fibroblasts. J Immunol. 2012; Jun 15;188(12): 6046-54.
Zhou, X, Wu, W, Hu, H, Milosevic, J, Konishi, K, Kaminski, N, Wenzel, SE. Genomic differences distinguish the myofibroblast phenotype of distal lung fibroblasts from airway fibroblasts. Am J Respir Cell Mol Biol. 2011; Dec;45(6): 1256-62.
Zhou, X, Hu, H, Huynh, ML, Kotaru, C, Balzar, S, Trudeau, JB, Wenzel, SE. Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts. J Allergy Clin Immunol. 2007; Jun;119(6): 1388-97.
Kotaru, C, Schoonover, KJ, Trudeau, JB, Huynh, ML, Zhou, X, Hu, H, Wenzel, SE. Regional fibroblast heterogeneity in the lung: implications for remodeling. Am J Respir Crit Care Med. 2006; Jun1;173(11): 1208-15.
Zhou, X, Trudeau, JB, Schoonover, KJ, Lundin, JI, Barnes, SM, Cundall, MJ, Wenzel, SE. Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts. Am J Physiol Cell Physiol. 2005; Feb;288(2): C435-42.
Wenzel, SE, Trudeau, JB, Barnes, S, Zhou, X, Cundall, M, Westcott, JY, McCord, K, Chu, HW. TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts. J Immunol. 2002; Oct 15;169(8): 4613-9.
Sponsored Research/Activities
Title: Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma - Project 2
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: P01 AI106684
Start Year: 2015
End Year: 2020
Title: Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U10 HL109152
Start Year: 2011
End Year: 2017