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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Jinming Zhao, PhD

Research Assistant Professor of Medicine

Email: zhaoj2@upmc.edu

Phone: 412-864-2615

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-864-2615
Fax: 412-605-1999
E-mail: zhaoj2@upmc.edu
Education and Training
Education
BS, Preventive Medicine, Hengyang Medical College, Hunan, China, 1993
MS, Environmental Toxicology, Nanhua University, Hunan, China, 2000
PhD, Molecular Toxicology, Fudan University Medical Center, Shanghai, China, 2003
Training
Postdoctoral Associate, Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 2006
Research Interest
Dr. Zhao’s research has been focused on the pathogenesis of severe asthma as it relates to the role of the 15-Lipoxygenase-1 (15LO1) signaling pathway. 15-Lipoxygenase 1 is one of several key enzymes involved in arachidonic acid (AA) metabolism. Using primary human airway epithelial cells as a model, Dr. Zhao’s research suggests that 15LO1 increases with severity of asthma and regulates MUC5AC gene expression. He was the first to show that 15LO1 interacts with Raf-1/PEBP1 to regulate MAPK/ERK signal pathway and amplify IL-4Ra signaling in human airway epithelial cells. These data suggest that the 15LO1 pathway could play a critical role in regulating gene expression which contributes to asthma pathogenesis. Dr. Zhao is particularly interested in the mechanism of 15LO1 expression in chronic Th2 background, the downstream effects of 15LO1 pathway activation on inflammatory gene expression and the key biologic activity of the 15LO1 enzyme products.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Albano, G, Zhao, J, Etling, E, Wenzel, SE, et al. IL-13 desensitizes ß2 adrenergic receptors in human airway epithelial cells through a 15-Lipoxygenase: G-protein receptor kinase 2 mechanism. J Allergy Clin Immunol. 2015; May;135(5): 1144-53.
Zhao, J, Wenzel, SE. Interactions of RKIP with inflammatory signaling pathways. Crit Rev Oncog. 2014; 19(6): 497-504.
Di, YP, Zhao, J, Harper, R. Cigarette smoke induces MUC5AC expression through the activation of Sp1. J Biol Chem. 2012; Aug 10;287(33): 27948-58.
Zhao, J, O'Donnell, VB, Balzar, S, St. Croix, CM, Trudeau, JB, Wenzel, SE. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A. 2011; Aug 23;108(34): 14246-51.
Zhao, J, Maskrey, B, Balzar, S, Chibana, K, Mustovich, A, Hu, H, Trudeau, JB, O'Donnell, V, Wenzel, SE. IL-13 induced MUC5AC is regulated by 15-Lipoxygenase (LO) 1 Pathway in Human Bronchial Epithelial Cells. Am J Respir Crit Care Med. 2009; May 1;179(9): 782-90.
Zhao, J, Harper, R, Barchowsky, A, Di, YP. Identification of multiple MAPK-mediated transcription factors regulated by tobacco smoke in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007; Aug;293(2): L480-90.