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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Jing Zhao, MD, PhD

Associate Professor of Medicine

Email: zhaoj@upmc.edu

Phone: 412-624-2075

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-2075
Fax: 412-383-7113
E-mail: zhaoj@upmc.edu
Administrative Assistant:
Roe Catley
Email: catlrx@upmc.edu
Phone: 412-624-8669
Fax: 412-383-7113
Education and Training
Education
MD, Dalian Medical University, China, 1994
PhD, Gifu University School of Medicine, Japan, 2001
Research Specialist, Johns Hopkins University School of Medicine, 2005
Postdoc Fellow, University of Chicago, 2007
Research Interest
Dr. Zhao’s research is to investigate histone acetyltransferase stability in acute lung injury. The ubiquitin-proteasome system is the major pathway of non-lysosomal intracellular protein degradation and controls pro- and anti-inflammatory responses by modulating immune regulatory signal protein turnover. Dr. Zhao is focusing on the role of de-ubiquitination enzyme USP14 and E3 ubiquitin ligase subunit FBXL19 in the regulation of CBP stability, activity, and histone acetylation in lung injury and sepsis.

Another research interest of Dr. Zhao is to determine the role of de-ubiquitination enzymes in the regulation of pulmonary endothelial integrity. She has identified that a novel de-ubiquitination enzyme plays a critical role in maintaining pulmonary endothelial barrier function. She is using proteomics tool, molecular and cellular biological techniques to reveal the molecular mechanisms by which the de-ubiquitination enzyme regulates VE-cadherin localization and cytoskeletal rearrangement.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Zhao, J., Camp, S. M., Chiang, E. T., Schilling, A. B., Dudek, S. M., Garcia, J. G. N. Phosphotyrosine protein dynamics in the lipid raft of sphingosine-1-phosphate-stimulated human endothelium: Role in barrier enhancement. Cellular Signaling. 2009; 21(12): 1945-60.
Zhao, J., Wei, J., Mialki, R. K., Mallampalli, D., Chen, B. B., Coon, T., Zou, C., Mallampalli, R. K., Zhao, Y. F-box protein FBXL19-mediated ubiquitination and degradation of the IL-33 receptor limits pulmonary inflammation. Nature Immunology. 2012; 13(7): 651-8.
Chen, B. B., Coon, T. A., Glasser, J. R., McVerry, B. J., Zhao, J., Zhao, Y., Zou, C., Ellis, B. M., Sciurba, F. C., Zhang, Y., Mallampalli, R. K. A combinatorial F box protein directed pathway controls TRAF stability to regulate inflammation. Nature Immunology. 2013; 14(5): 470-9.
Wei, J., Mialki, R. K., Dong, S., Khoo, A., Mallampalli, R. K., Zhao, Y., Zhao, J. A new mechanism of RhoA ubiquitination and degradation: Roles of SCFFBXL19 E3 ligase and Erk2. Biochimica et Biophysica Acta. 2013; 1833(12): 2757-64.
Dong, S., Khoo, A., Wei, J., Bowser, R. K., Weathington N. M>, Xiao, S., Zhang, L., Ma, H., Zhao, Y., Zhao, J. Serum starvation regulates E-cadherin up-regulation via activation of c-Src in non-small-cell lung cancer A549 cells. American Journal of Physiology Cellular Physiology. 2014; 307(9): C893-9.
Sponsored Research/Activities
Title: Regulation of Histone Acetyltransferase Stability in Sepsis
Role: Principal Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R01 GM115389
Start Year: 2015
End Year: 2020
Title: Role of the Ubiquitin-Proteasome System in Histone Acetylation in Acute Lung Injury
Role: Principal Investigator
Funding Agency: American Lung Association
Start Year: 2015
End Year: 2017
Title: FBXL19 Protects Acute Lung Injury by Degradation of ST2L
Role: Principal Investigator
Funding Agency: American Heart Association-National
Start Year: 2012
End Year: 2015
Title: Regulation of Proteolysis by Deubiquiting Enzyme in Lung Inflammatory Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL131665
Start Year: 2017
End Year: 2021
Title: Mechanisms of Lung Homeostatis by F box Proteins
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL097376
Start Year: 2014
End Year: 2018
Title: Regulation of F Box Proteins in Acute Lung Injury
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL081784
Start Year: 2014
End Year: 2018
Title: Cardiolipin as a Novel Mediator of Acute Lung Injury (Core A)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2014
End Year: 2018
Title: A New Genus of Ubiquitin-Based Anti-Inflammatories for COPD
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: UH2 HL123520
Start Year: 2014
End Year: 2017
Notable Achievements
MWAFMR Scholar Award, 2012
Henry Christian Award, 2013
Editorial Board Member for SM Vascular Medicine, 2015
Grant Reviewer for French National Research Agency, 2016
Grant reviewer, French National Research Agency, 2016
Member, American Thoracic Society
Member, American Federation for Medical Research
Member, American Association for Mass Spectromery