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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Xingan Wang, MD, PhD

Assistant Professor of Medicine

Email: wangx17@upmc.edu

Phone: 412-648-7784

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-648-7784
Fax: 412-692-2260
E-mail: wangx17@upmc.edu
Administrative Assistant:
Arianna Garcia
Email: garciaal@upmc.ed
Phone: 412-648-7784
Fax: 412-692-2260
Education and Training
Education
Doctorate, The Second Military Medical University in Shanghai, 2009
Master, Shanghai Jiao Tong University School of Medicine, 2000
Bachelor of Medicine, Tongji University School of Medicine, 1994
Training
Postdoctoral Research Associate, Washington University in St. Louis, 2013
Postdoctoral Research Associate, Fudan University Shanghai Medical College, 2011
Research Interest
My research interest is “bridging” the bench and the bedside in three areas of lung transplantation: donor shortage, ischemia-reperfusion injury and transplant rejection. As a scientist with 11 years of experience in thoracic surgery, I know what both sides need. By taking surgical skills and medical care from bedside back to bench, I refined and established the mouse models of lung transplantation, intravital Two-photon imaging and Serial intravital imaging. Hyaluronan accumulation and pseudomonas infection were found to be related to clinical lung allograft rejection. Our studies revealed the mechanisms and explored potential prevention with animal models. Neutrophil extracellular traps (NETs) are recently reported to be involved in neutrophil-induced damage. Our recent study visualized neutrophil extracellular traps (NETs) and revealed their special roles in ischemia reperfusion injury and rejection in our mouse lung transplant model. Eliminating NETs with such drugs as DNase would worsen the lung injury and rejection. Our ongoing study is expected to provide even greater understanding of the mechanism and will go further to explore potential therapeutic targets. Multidisciplinary collaboration is another aspect. Collaborating with the specialists in micro positron emission tomography (PET) and micro magnetic resonance imaging (MRI), we explored some new non-invasive diagnostic methods for acute rejection in mouse lung transplants. The last but the most promising, our ongoing research combines lung transplantation and Ex Vivo Lung Perfusion (EVLP) in mice. That would accelerate the translational study on EVLP and non-heart-beating donor lung, alleviating the donor shortage.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Todd JL (Co-first author), Wang X (Co-first author), Sugimoto S, Kennedy VE, Zhang HL, Pavlisko EN, Kelly FL, Huang H, Kreisel D, Palmer SM, Gelman AE. Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity. Am J Respir Crit Care Med. 2014; 189(5): 556-66.
Ibrahim M (Co-first author), Wang X (Co-first author), Puyo CA, Montecalvo A, Huang HJ, Hachem RR, Andreetti C, Menna C, Chen R, Krupnick AS, Kreisel D, Rendina EA, Gelman AE. Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury. J Heart Lung Transplant. 2015; 34(2): 247-53.
Chen DL, Wang X, Yamamoto S, Carpenter D, Engle JT, Li W, Lin X, Kreisel D, Krupnick AS, Huang HJ, Gelman AE. Increased T cell glucose uptake reflects acute rejection in lung grafts. Am J Transplant. 2013; 13(10): 2540-9.