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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Prithu Sundd, PhD

Assistant Professor of Medicine and Bioengineering

Email: prs51@pitt.edu

Phone: 412-648-9103

Contact
Office: Starzl Biomedical Science Tower, E1255
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-9103
Fax: 412-648-5980
E-mail: prs51@pitt.edu
Administrative Assistant:
Carla Monzo
Email: monzocm@upmc.edu
Phone: 412-383-5853
Fax: 412-648-5980
Education and Training
Education
B.Tech., Biochemical Engineering, Harcourt Butler Technological Institute, Kanpur, India, 2001
PhD, Chemical Engineering, Ohio University, 2007
Research Interest
1. Mechanisms of leukocyte rolling and arrest during inflammation.
2. Role of neutrophils in pulmonary vaso-occlusion during sickle cell disease Acute Chest Syndrome.
3. Identifying molecular mechanism of vaso-occlusion in SCD (SS) patient blood.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Jimenez, MA, Tutuncuoglu, E, Barge, S, Novelli, EM, Sunnd, P. Quantitative microfluidic fluorescence microscopy to study vaso-occlusion in Sickle Cell Disease. Haematologica. 2015; May 14.
Bennewitz, MF, Watkins, SC, Sundd, P. Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice. Intravital. 2014; Jul 7;3(2): e29748.
Koltsova, EK, Sundd, P, Zarpellon, A, Ouyang, H, Mikulski, Z, Zampolli, A, Ruggeri, ZM, Ley, K. Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thrombosis and Haemostasis. 2014; Dec; 112(6): 1252-63.
Stadtmann, A, Germena, G, Block, H, Boras, M, Rossaint, J, Sundd, P, Lefort, C, Fisher, CI, Buscher, K, Gelschefarth, B, Urzainqui, A, Gerke, V, Ley, K, Zarbock, A. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. Journal of Experimental Medicine. 2013; Oct 21;210(11): 2171-80.
Sundd, P, Ley, K. Quantitative dynamic footprinting microscopy. Immunology and Cell Biology. 2013; Apr;91(4): 311-20.
Sundd, P, Pospieszalska, MK, Ley, K. Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings. Molecular Immunology. 2013; Aug;55(1): 59-69.
Sundd, P, Gutierrez, E, Koltsova, EK, Kuwano, Y, Fukuda, S, Pospieszalska, MK, Groisman, A, Ley, K. 'Slings' enable neutrophil rolling at high shear. Nature. 2012; Aug 16;488(7411): 399-403.
Sundd, P, Pospieszalska, MK, Cheung, LS, Kostantopoulos, K, Ley, K. Biomechanics of leukocyte rolling. Biorheology. 2011; 48(1): 1-35.
Sundd, P, Gutierrez, E, Petrich, BG, Ginsberg, MH, Groisman, A, Ley, K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011; Jul;18(5): 361-72.
Sundd, P, Gutierrez, E, Pospieszalska, MK, Zhang, H, Groisman, A, Ley, K. Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling. Nature Methods. 2010; Oct;7(10): 821-4.
Sponsored Research/Activities
Title: Pulmonary Arteriole Occlusion by Platelet-Neutrophil Micro-Emboli in Acute Chest Syndrome
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128297
Start Year: 2015
End Year: 2020
Title: Dual Color Dynamic Footprinting Reveals Mechanisms of Leukocyte Rolling and Arrest During Inflammation
Role: Principal Investigator
Funding Agency: American Heart Association-National
Start Year: 2013
End Year: 2015
Title: HIPPO Signaling in Pulmonary Arterial Hypertension
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL130261
Start Year: 2016
End Year: 2020
Title: PPAR-delta as a Novel Therapeuic Target in Asthma (Admin Supplement)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI125338
Start Year: 2016
End Year: 2019
Title: Hemolysis Induced Platelet Activation Requires Mitochondrial Signaling
Role: Co-Investigator
Funding Agency: American Heart Association-National
Grant Number: RES
Start Year: 2016
End Year: 2017