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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Timothy B. Oriss, PhD

Research Associate Professor of Medicine

Email: tio5@pitt.edu

Phone: 412-802-3219

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-802-3219
Fax: 412-692-2260
E-mail: tio5@pitt.edu
Administrative Assistant:
Patty Geraci
Email: geracip@upmc.edu
Phone: 412-692-2118
Fax: 412-692-2260
Education and Training
Education
BS, Biology/Chemistry, Indiana University of PA, 1984
MS Hyg, Virology, University of Pittsburgh Graduate School of Public Health, 1988
PhD, University of Pittsburgh Graduate School of Public Health, 1993
Training
Postdoctoral Training, Immunology, University of Pittsburgh Cancer Institute, 1998
Postdoctoral Training, Rheumatology and Clinical Immunology, University of Pittsburgh, 2000
Research Interest
During his doctoral thesis work, Dr. Oriss studied the role of Epstein-Barr virus in post-transplant lymphoproliferative disorders. This sparked his interest in immunology, which he then pursued during two post-doctoral fellowships. During the first, he studied cytokine crossregulation between murine T helper type 1 and T helper type 2 cells. And during the second, he studied human T cell responses to autoantigens stimulated by dendritic cells in the setting of the autoimmune disease, systemic sclerosis, also commonly known as scleroderma.
More recently, Dr. Oriss has focused on many aspects of dendritic cell biology in lung disease, particularly asthma. He developed a murine model of experimental airway inflammation utilizing direct sensitization to allergen via the airways which has facilitated the study of DC-mediated priming events in the lung-draining lymph nodes. This basic methodology has been adapted for other experimental systems by a number of others in the laboratory. He received a Dalsemer Award from the American Lung Association in 2007 to study effects of agonists of PPAR-g on DC migration in vivo, and is a co-investigator on a number of grants involving DC biology. Dr. Oriss has collaborative efforts with the laboratory of Sally Wenzel MD to study the basic biology of severe asthma in humans.
Dr. Oriss has a long-standing interest in flow cytometry and he is primarily responsible for the operation and maintenance of two flow cytometers. His expertise with flow cytometry has led to a number of collaborative efforts with investigators within, as well as outside of PACCM.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Raundhal, M., Morse, C., Khare, A., Oriss, T.B., Milosevic, J., Trudeau, J., Pilewski, J., Holguin, F., Kolls, J., Wenzel, S., Ray, P., Ray, A. High IFN-gamma and low SLPI mark severe asthma in mice and humans. Journal of Clinical Investigation. 2015; 125(8): 3037.
Oriss, T.B., Ostroukhova, M., Stolz, D.B., Watkins, S.C., Pillemer, B., Ray, P., Ray, A. Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T cells in airway inflammation and tolerance. Journal of Immunology. 2005; 174(2): 854.
Ray, A., Raundhal, M., Oriss, T.B., Ray, P., Wenzel, S.E. Current concepts of severe asthma. Journal of Clinical Investigation. 2016; 126(7): 2394.
Oriss, T.B., Krishnamoorthy, N., Raundhal, M., Morse, C., Chakraborty, K., Khare, A., Huff, R., Ray, P., Ray, A. Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response. Journal of Immunology. 2014; 192(12): 5471.
Ray, A., Oriss, T.B., Wenzel, S.E. Emerging Molecular Phenotypes of Asthma. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2015; 308(2): L130.
Oriss, T.B., Krishnamoorthy, N., Ray, P., Ray, A. Dendritic cell c-kit signaling and adaptive immunity: implications for the upper airways. Current Opinion in Allergy and Clinical Immunology. 2014; 14(1): 7.
Khare, A., Krishnamoorthy, N., Oriss, T.B., Fei, M., Ray, P., Ray, A. Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance. Journal of Immunology. 2013; 191(1): 25.
Krishnamoorthy, N., Khare, A., Oriss, T.B., Raundhal, M., Morse, C., Yarlagadda, M., Wenzel, S.E., Moore, M.L., Peebles, R.S., Ray, A., Ray, P. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nature Medicine. 2012; 18(10): 1525.
Xu, H., Oriss, T.B. (*co-1st author), Fei, M., Henry, A.C., Melgert, B.N., Chen, L., Mellor, A.L., Munn, D.H., Irvin, C.G., Ray, P., Ray, A. Indoleamine 2,3-dioxygenase in Lung Dendritic Cells Promotes Th2 Responses and Inflammation. Proceedings of the National Academy of Sciences USA. 2008; 105(18): 6690.
Krishnamoorthy, N., Oriss, T.B., Paglia, M., Fei, M., Vanhaesebroeck, B., Ray, A., Ray, P. Activation of the c-kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nature Medicine. 2008; 14(5): 565.
Sponsored Research/Activities
Title: Mechanisms of Antigen-Induced Tolerance in the Lung
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI048927
Start Year: 2016
End Year: 2021
Title: Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2014
End Year: 2018
Title: Mechanisms of Antigen Induced Tolerance in the Lung
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI048927
Start Year: 2011
End Year: 2016
Title: Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma - Core B
Role: Core Leader
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: P01 AI106684
Start Year: 2015
End Year: 2020
Title: Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
Role: Staff Scientist
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI100012
Start Year: 2012
End Year: 2017
Notable Achievements
Institutional National Research Service Award, National Institutes of Health, 1999-2001
Dalsemer Award, American Lung Association, 2007-2009