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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Michael M. Myerburg, MD

Associate Professor of Medicine

Email: myerburgm@upmc.edu

Phone: 412-624-8669

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15122
 
Phone: 412-624-8669
Fax: 412-383-7113
E-mail: myerburgm@upmc.edu
Administrative Assistant:
Roe Catley
Email: catlrx@upmc.edu
Phone: 412-624-8669
Fax: 412-383-7113
Education and Training
Education
BA, Biology, Colorado College, 1994
MD, University of Pittsburgh School of Medicine, 2000
Training
Residency, Internal Medicine, University of Pittsburgh School of Medicine, 2003
Fellowship, Pulmonary and Critical Care, University of Pittsburgh School of Medicine, 2006
Post-Doctoral Scholar, Pulmonary, University of Pittsburgh School of Medicine, 2007
Research Interest
Dr. Myerburg’s primary research interest is to determine the mechanisms and pathological conditions associated with hydration of the airway lumen. To this end, he has extensive experience with several techniques to measure the airway surface liquid (ASL) volume, ciliary beat frequency, and airway epithelial ion transport. He has developed novel high-throughput techniques to measure ASL volume and ASL pH.

Dr Myerburg's lab is currently studying the effects of Th2 type cytokines on ASL volume, airway innate immunity, the role of several transport proteins on ASL hydration, and post-translational modifications to the epithelial sodium channel (ENaC). These projects are funded by the NIH and the Cystic Fibrosis Foundation.
Clinical Interest
Dr. Myerburg’s clinical expertise focuses on cystic fibrosis lung disease, general pulmonary medicine, and critical care.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Heidrich, E, Carattino, MD, Hughey, RP, Pilewski, JM, Kleyman, RT, Myerburg, MM. Intracellular Na+ regulates epithelial Na+ channel maturation. J Biol Chem. 2015; Mar 12: (Epubaheadofprint).
Harvey, PR, Tarran, R, Garoff, S, Myerburg, MM. Measurement of the airway surface liquid volume with simple light refraction microscopy. Am J Respir Cell Mol Biol. 2011; Sep;45(3): 592-9.
Myerburg, MM, Harvey, PR, Heidrich, EM, Pilewski, JM, Butterworth, M. Acute regulation of ENaC in airway epithelia by proteases and trafficking. Am J Respir Cell Mol Biol. 2010; Dec;43(6): 712-9.
Myerburg, MM, Butterworth, MB, McKenna, EE, Peters, KW, Frizzell, RA, Kleyman, TR, Pilewski, JM. Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis. J Biol Chem. 2006; Sep 22;281(38): 27942-9.
Sponsored Research/Activities
Title: Human Airway Cell and Tissue - Core A
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2015
End Year: 2019
Title: Basic and Translational Studies of Cystic Fibrosis (Core A)
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK072506
Start Year: 2015
End Year: 2018
Title: Th2 Inflammation Promotes Airway Surface Liquid Dehydration
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112863
Start Year: 2012
End Year: 2017
Title: Imaging Airway Liquid Absorption in Cystic Fibrosis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL108929
Start Year: 2011
End Year: 2017
Title: pH Dependent Matriptase Activation Promotes Sodium Hyperabsorption in CF
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2011
End Year: 2013
Notable Achievements
The Cystic Fibrosis Foundation Harry Shwachman Clinical Investigator Award, 2007
NIH Mentored Clinical Scientist Career Development Award (K08), 2007
PACCM Outstanding Young Investigator Award, 2012
Ad Hoc Reviewer, NIH Eary CF Lung Disease RFA, 2012
Ad Hoc Reviewer, NIH LCMI study section, 2013-2014
Ad Hoc Reviewer, The Cystic Fibrosis Foundation, 2015- present