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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Timothy E. Corcoran, PhD

Associate Professor of Medicine and Bioengineering

Email: corcorante@upmc.edu

Phone: 412-624-8669

Contact
Office: W1256 Starzl Biomedical Science Tower
203 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-624-8669
Fax: 412-383-7113
E-mail: corcorante@upmc.edu
Administrative Assistant:
Roe Catley
Email: catlrx@upmc.edu
Phone: 412-624-8669
Fax: 412-383-7113
Education and Training
Education
BS, Engineering, Lehigh University, 1990
Masters of Science, Mechanical Engineering, Lehigh University, 1992
PhD, Bioengineering, Carnegie Mellon University, 2002
Training
Post-Doctoral Fellowship - Pulmonary, University of Pittsburgh, 2002
Research Interest
Dr. Corcoran’s primary research interests include aerosol drug delivery and aerosol-based nuclear imaging of the lung. He has been extensively involved in the development of inhaled medications for lung transplant recipients and cystic fibrosis patients and the development special techniques for improving inhaled drug delivery such as the use of low density gases and surfactants to improve drug distribution in the lungs. Dr. Corcoran had developed imaging techniques for quantifying pulmonary physiology including measurements of mucociliary clearance and liquid absorption in the airways. These techniques have been tested in a series of clinical studies involving adult and pediatric patients and will be used to screen new medications for treating lung diseases such as cystic fibrosis. Dr. Corcoran is currently the Principal Investigator of two NIH RO1 grants. He has previously directed research funded by the U.S. Army and the Cystic Fibrosis Foundation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Locke LW, Myerburg MM, Weiner DJ, Markovetz MR, Parker RS, Muthukrishnan A, Weber L, Czachowski MR, Lacy RT, Pilewski JM, Corcoran TE. Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung. The European Respiratory Journal. 2016; 47: 1392.
Locke, LW, Myerburg, MM, Markovetz, MR, Parker, RS, Weber, L, Czachowski, MR, Harding, TJ, Brown, SL, Nero, JA, Pilewski, JM, Corcoran, TE. Quantitative Imaging of Airway Liquid Absorption in Cystic Fibrosis. Eur Resp J. 2014; 44(3): 675-84.
Markovetz, MR, Corcoran, TE, Locke, LW, Myerburg, MM, Pilewski, JM, Parker, RS. A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis. PLoS One. 2014; Nov 10: 9(11).
Corcoran, TE, Thomas, KM, Brown, S, Myerburg, MM, Locke, LW, Pilewski, JM. Liquid hyper-absorption as a cause of increased DTPA clearance in the cystic fibrosis airway. EJNMMI Res. 2013; 27; 3(1): 14.
Sponsored Research/Activities
Title: Building Multilevel Models of Therapeutic Response in the Lungs
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL131046
Start Year: 2016
End Year: 2020
Title: Estimation of Pulmonary Aerosol Deposition of Voriconazole
Role: Principal Investigator
Funding Agency: University Health Network/Pfizer Inc.
Start Year: 2013
End Year: 2013
Title: Imaging Airway Liquid Absorption in Cystic Fibrosis
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL108929
Start Year: 2011
End Year: 2017
Title: Peak Cough Flow and Airway Clearance in Pediatric Neuromuscular Disease
Role: Co-Principal Investigator
Funding Agency: RespirTech Technologies
Start Year: 2013
End Year: 2016
Title: Th2 Inflammation Promotes Airway Surface Liquid Dehydration
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112863
Start Year: 2012
End Year: 2017
Title: Improving Inhaled Drug Delivery with Self-Dispersing Surfactant Films
Role: Co-Principal Investigator
Funding Agency: Carnegie-Mellon University/National Heart, Lung, & Blood Institute
Grant Number: R01 HL105470
Start Year: 2011
End Year: 2016
Title: Respiratory Ciliary Dysfunction and Pulmonary Risks in Congenital Heart Disease Patients
Role: Co-Investigator
Funding Agency: Department of Defense
Start Year: 2015
End Year: 2018
Title: ACTIVATE-CF: Effects of a 6 Month Partially Supervised Conditioning Program In CF: An International Multi-Center Randomized Controlled
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2014
End Year: 2016
Title: Red Cell Transfusion: Modifier of Lung and Systemic Inflammatory Responses
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL086844
Start Year: 2013
End Year: 2018
Title: Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI100012
Start Year: 2012
End Year: 2017
Title: Basic and Translational Studies of Cystic Fibrosis - Core B
Role: Associate Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK072506
Start Year: 2015
End Year: 2018
Title: A Two-Part Multicenter Prospective Longitudinal Study of CFTR-Dependent Disease Profiling in Dystic Fibrosis (PROSPECT)
Role: Research Assistant
Funding Agency: Seattle Childrens Hospital/Cystic Fibrosis Foundation
Start Year: 2014
End Year: 2016
Notable Achievements
Pitt Greek Hall of Fame, 2016
Pitt Innovation Challenge Competition winner, 2014
Cathedral Award, Student Group Advising, University of Pittsburgh, 2013
Cathedral Award, Student Group Advising, University of Pittsburgh, 2009
Pitt Innovator Award, 2008
Young Investigator Award, International Society for Aerosols in Medicine, 2007