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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Beibei Bill Chen, PhD

Associate Professor of Medicine

Director, Small Molecule Therapeutic Center

Co-Director, Acute Lung Injury Center of Excellence

Email: chenb@upmc.edu

Phone: 412-624-8669

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-8669
Fax: 412-383-7113
E-mail: chenb@upmc.edu
Administrative Assistant:
Roe Catley
Email: catlrx@upmc.edu
Phone: 412-624-8669
Fax: 412-383-7113
Education and Training
Education
BS, Chemistry, Wuhan University, 2003
PhD, Biochemistry, University of Iowa, 2008
Training
Post-doctoral Fellow, University of Iowa, 2009
Research Interest
Dr. Chen’s primary research interest includes the study of the molecular mechanisms that control inflammation and cell proliferation via protein ubiquitination. Specifically, over the last four years, He have successfully identified and characterized over 10 novel ubiquitin E3 ligases. These works have been published in top-tier journals related to protein ubiquitination—including Nature Immunology, Nature Medicine, Cell Reports and Science Translational Medicine, Journal of Experimental Medicine. His second area of research interest is small molecule drug design. In the past two years, he has submitted 10 provisional patents related to novel anti-inflammatory/cancer compounds. In addition, he have successfully designed and synthesized a novel series of first-in-class small molecule FBXO3 protein inhibitors. One of his lead compounds, BC-1261, has passed preclinical PK/toxicity studies and was discussed at an FDA pre-IND meeting in May 2015. This compound is currently on track to a Phase I trial in August 2017. Recently, he has also designed a novel series of potent, selective PDE4, HECTD2, StamBP, Fbxo7, Fbxo48, FIEL1, DCN1 inhibitors that exhibit excellent activities in vivo. His long-term goal is to develop a new class of therapeutics that combat caner and inflammatory diseases by focusing on novel mechanisms.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Lear T, McKelvey AC, Rajbhandari S, Coon TA, Connelly W, Zhao J, Dunn SR, Liu Y, Zhang Y, Kass DJ, Chen BB. Ubiquitin E3 Ligase FIEL1 Regulates Fibrotic Lung Injury through SUMO-E3 Ligase PIAS4. J Exp Med. 2016; May 30;213(6): 1029-46.
Zou, C, Li, J, Xiong, S, Chen, Y, Wu, Q, Weathington, NM, Han, SY, Snavely, C, Chen, BB, Mallampalli, RK. Mortality factor 4 like 1 (Morf4l1) protein mediates epithelial cell death in experimental pneumonia. Sci Trans Med. 2015; Oct 28;7(311): 311ra171.
Liu, Y, Lear, T, Iannone, O, Shiva, S, Corey, C, Rajbhandari, S, Chen, BB, Mallampalli, RK. Pro-apoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin. J Biol Chem. 2015; Mar 16.
Han, S, Lear, T, Rajbhandari, S, Chen, BB, Mallampalli, RK. Lipopolysaccharide primes the NALP3 inflammasome by inhibiting its ubiquitination and degradation mediated by the SCFFBXL2 E3 ligase. J Biol Chem. 2015; Jul 17;290(29): 18124-33.
Coon, TA, McKelvey, AC, Lear, T, Rajbhandari, S, Dunn, RS, Connelly, W, Zhao, J, Han, S, Liu, Y, McVerry, BJ, Zhang, Y, Chen, BB. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Trans Med. 2015; Jul8;7(295): 295ra109.
Coon, TA, McKelvey, AC, Weathington, NM, Birru, RL, Lear, T, Leikauf, GD, Chen, BB. Novel PDE4 Inhibitors Derived From Chinese Medicine Forsythia. PLOS ONE. 2014; Dec 30;9(12): e115937.
Chen, BB, Coon, TA, Glasser, JR, Zou, C, Ellis, B, Das, T, McKelvey, AC, Rajbhandari, S, Lear, T, Kamga, C, Shiva, S, Li, C, Pilewski, JM, Callio, J, Chu, CT, Ray, A, Ray, P, Tyurina, YY, Kagan, VE, Mallampalli, RK. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Reports. 2014; Apr 24; 7(2): 476-87.
Chen, BB, Coon, TA, Glasser, JR, McVerry, BJ, Zhao, J, Zhao, Y, Aou, C, Ellis, BM, Sciurba, FC, Zhang, Y, Mallampalli, RK. A combinatorial F box protein directed pathway controls TRAF stability to regulate inflammation. Nat Immunol. 2013; Mar 31.
Mallampalli, RK, Coon, TA, Glasser, JR, Wang, C, Dunn, SR, Weathington, NM, Zhao, J, Zou, C, Zhao, Y, Chen, BB. Targeting F box protein Fbxo3 to control cytokine-driven inflammation. J Immunol. 2013; Nov 15;191(10): 5247-55.
Coon, TA, Glasser, JR, Mallampalli, RK, Chen, BB. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012; Feb 15; 11(4): 721-9.
Sponsored Research/Activities
Title: Regulation of Innate Immunity by F-Box Proteins
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL116472
Start Year: 2013
End Year: 2018
Title: Stabilizing Mitochondria in Sepsis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098174
Start Year: 2017
End Year: 2021
Title: F box-Induced Acute Lung Injury and Parkin
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL096376
Start Year: 2016
End Year: 2020
Title: Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI119042
Start Year: 2015
End Year: 2017
Title: A New Genus of Ubiquitin-Based Anti-Inflammatories for COPD
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: UH2 HL123520
Start Year: 2015
End Year: 2016
Title: Regulation of F Box Proteins in Acute Lung Injury
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL081784
Start Year: 2014
End Year: 2018
Title: Novel F Box Anti-Inflammatories for COPD
Role: Co-Investigator
Funding Agency: Flight Attendants Medical Research Institute
Start Year: 2014
End Year: 2017
Title: Hemostasis and Vascular Biology Research Institute - Chen
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Start Year: 2013
End Year: 2028
Notable Achievements
Munich/Pittsburgh International Lung Conference Investigator Award, 2015
Pitt Innovator Award, 2014
Pittsburgh International Lung Conference Peer Award, 2012