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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Marta Bueno, PhD

Research Assistant Professsor of Medicine

Email: mbueno@pitt.edu

Phone: 412-624-2132

Contact
Office: Vascular Medicine Institute
E1200-24B Biomedical Science Tower
Pittsburgh, PA 15213
 
Phone: 412-624-2132
Fax: 412-648-9009
E-mail: mbueno@pitt.edu
Administrative Assistant:
Carla Monzo
Email: monzocm@upmc.edu
Phone: 412-383-5853
Fax: 412-648-5980
Education and Training
Education
BSc in Biochemistry, University of Zaragoza (Spain), 2000
Erasmus Fellowship, University of Geneva (Switzerland), 2000
Master in Biochemistry, University of Zaragoza (Spain), 2006
PhD in Biochemistry (Protein Folding and Molecular Design), University of Zaragoza (Spain), 2006
Thomas E. Starzl Transplantation Fellowship, School of Medicine, 2007
Research Interest
Idiopathic Pulmonary Fibrosis (IPF) is a fatal and progressive lung disease, characterized by progressive scarring of the lung. IPF prevalence dramatically increases with age, and aging is a known risk factor for IPF. However, there is limited understanding in the mechanisms involved in the increased vulnerability of the aging lung to develop lung fibrosis. Our published findings were pioneered to identify alterations in mitochondrial homeostasis in the aging type alveolar epithelial cell (AECII) as a critical component of the pathogenesis of IPF. Currently, our studies are extending to other diseases characterized by abnormal tissue repair and exaggerated remodeling, including pulmonary hypertension (PH) and scleroderma.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bueno, M., Lai, Y. C., Romero, Y., Brands, J., St Croix, C. M., Kamga, C., Corey, C., Herazo-Maya, J. D., Sembrat, J., Lee, J. S., Duncan, S. R., Rojas, M., Shiva, S., Chu, C. T., Mora, A. L. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. Journal of Clinical Investigation. 2015; 125(2): 521-38.
Torres-González, E., Bueno, M., Tanaka, A., Krug, L. T., Cheng, D. S., Polosukhin, V. V., Sorescu, D., Lawson, W. E., Blackwell, T. S., Rojas, M., Mora, A. L. Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2012; 46(6): 748-56.
Bueno, M., Wang, J., Mora, A. L., Gladwin, M. T. Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. Antioxidants & Redox Signaling. 2013; 18(14): 1797-809.
Acín-Pérez, R., Bayona-Bafaluy, M.P., Bueno, M., Machicado, C., Fernández-Silva, P., Pérez-Martos, A., Montoya, J, Lopez-Perez, M. J., Sancho, J., Antonio Enríquez, J. An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA. Human Molecular Genetics. 2003; 12(3): 329-339.
Chunqing, L, Bueno, M., Kant, J, Martinson, J, Randhawa, P. Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis. Journal of virology. 2009; 83(9): 2285-2297.
Bueno, M., Fillat, M. F., Strasser, R. J., Maldonado-Rodriguez, R., Marina, N, Smienk, H, Gómez-Moreno, C, Barja, F. Effects of lindane on the photosynthetic apparatus of the cyanobacteriumanabaena. Environmental Science and Pollution Research. 2004; 11(2): 98-106.